DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Trang Huyen Le | ko |
dc.contributor.author | Yu, Jeong Heon | ko |
dc.contributor.author | Jun, Hwiseok | ko |
dc.contributor.author | Yang, Moon Young | ko |
dc.contributor.author | Yang, Mi-Jin | ko |
dc.contributor.author | Cho, Jae-Woo | ko |
dc.contributor.author | Kim, Jin Woong | ko |
dc.contributor.author | Kim, Jee-Seon | ko |
dc.contributor.author | Nam, Yoon Sung | ko |
dc.date.accessioned | 2017-11-08T05:45:16Z | - |
dc.date.available | 2017-11-08T05:45:16Z | - |
dc.date.created | 2017-11-06 | - |
dc.date.created | 2017-11-06 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.citation | BIOMATERIALS, v.145, pp.223 - 232 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10203/226904 | - |
dc.description.abstract | Despite the excellent biocompatibility and antifouling effect of poly(ethylene glycol) (PEG), the high steric hindrance, limited chemical functionality, and low ligand multivalency of PEGylated nanocarriers often lead to inefficient cell targeting and intracellular trafficking. Hence, a new structure of hydrophilic corona allowing a higher ligand density without loss of excellent biocompatibility is highly desirable. Here we introduce tumor-targeted polyglycerolated (PGylated) nanocarriers that dramatically enhance the in vivo therapeutic efficacy of incorporated paclitaxel simply by increasing the surface density of hydrophobic tumor-targeting ligands. Linear polyglycerol-poly (e-caprolactone) block copolymer (PG-b-PCL) is used to prepare PGylated lipiodol nanoemulsions, where PG serves as a corona conjugated with a large number of folic acid (FA) for efficient tumor targeting. Unlike FA-PEGylated nanoemulsions, FA-PGylated nanoemulsions can display a larger number of FA without structural destabilization. This property enables excellent anti-cancer activities and effective tumor regression in a cervical cancer xenograft murine model at a cumulative drug dose of similar to 5 mg kg(-1), which is about four fold smaller than that of commercial Taxol formulation. This study highlights the importance of surface chemistry of nanocarriers that enable multivalent ligand functionalization and high tolerance to the conjugation of hydrophobic ligands, which make PG as a very effective hydrophilic corona for in vivo drug delivery. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | POLY(ETHYLENE GLYCOL) | - |
dc.subject | HYPERBRANCHED POLYGLYCEROL | - |
dc.subject | LINEAR POLYGLYCIDOL | - |
dc.subject | PEG NANOPARTICLES | - |
dc.subject | BLOCK-COPOLYMERS | - |
dc.subject | PROTEIN | - |
dc.subject | NANOEMULSIONS | - |
dc.subject | NANOCAPSULES | - |
dc.subject | SYSTEM | - |
dc.title | Polyglycerolated nanocarriers with increased ligand multivalency for enhanced in vivo therapeutic efficacy of paclitaxel | - |
dc.type | Article | - |
dc.identifier.wosid | 000413135200018 | - |
dc.identifier.scopusid | 2-s2.0-85028723689 | - |
dc.type.rims | ART | - |
dc.citation.volume | 145 | - |
dc.citation.beginningpage | 223 | - |
dc.citation.endingpage | 232 | - |
dc.citation.publicationname | BIOMATERIALS | - |
dc.identifier.doi | 10.1016/j.biomaterials.2017.08.042 | - |
dc.contributor.localauthor | Nam, Yoon Sung | - |
dc.contributor.nonIdAuthor | Kim, Trang Huyen Le | - |
dc.contributor.nonIdAuthor | Yang, Moon Young | - |
dc.contributor.nonIdAuthor | Yang, Mi-Jin | - |
dc.contributor.nonIdAuthor | Cho, Jae-Woo | - |
dc.contributor.nonIdAuthor | Kim, Jin Woong | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Linear polyglycerol | - |
dc.subject.keywordAuthor | Tumor targeting | - |
dc.subject.keywordAuthor | Ligand multivalency | - |
dc.subject.keywordAuthor | Nanoemulsions | - |
dc.subject.keywordAuthor | Paclitaxel | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | HYPERBRANCHED POLYGLYCEROL | - |
dc.subject.keywordPlus | LINEAR POLYGLYCIDOL | - |
dc.subject.keywordPlus | PEG NANOPARTICLES | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NANOEMULSIONS | - |
dc.subject.keywordPlus | NANOCAPSULES | - |
dc.subject.keywordPlus | SYSTEM | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.