DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Dongsun | ko |
dc.contributor.author | Kim, Heegon | ko |
dc.contributor.author | Oh, Ji Eun | ko |
dc.contributor.author | Jung, Hi Eun | ko |
dc.contributor.author | Lee, Yun Soo | ko |
dc.contributor.author | Park, Ji-Ho | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2017-08-08T06:47:33Z | - |
dc.date.available | 2017-08-08T06:47:33Z | - |
dc.date.created | 2017-08-07 | - |
dc.date.created | 2017-08-07 | - |
dc.date.created | 2017-08-07 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | ONCOTARGET, v.8, no.29, pp.47440 - 47453 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://hdl.handle.net/10203/225223 | - |
dc.description.abstract | Tumor immunotherapy aims to overcome the immunosuppressive microenvironment within tumors, and various approaches have been developed. Tumor-associated T regulatory cells (Tregs) suppress the activation and expansion of tumor antigen-specific effector T cells, thus, providing a permissive environment for tumor growth. Therefore, optimal strategies need to be established to deplete tumor-infiltrated Tregs because systemic depletion of Tregs can result in reduced anti-tumor effector cells and autoimmunity. Here, to selectively deplete Tregs in tumors, we intratumorally injected anti-CD25 antibodies conjugated to Chlorin e6 (Ce6), a photosensitizer that absorbs light to generate reactive oxygen species. Local depletion of tumor-associated Tregs with photodynamic therapy (PDT) inhibited tumor growth, which was likely due to the altered tumor immune microenvironment that was characterized by increased infiltration of CD8+ effector T cells and the expression of IFN-gamma and CD107a, which is a cytolytic granule exocytosis marker in tumor tissues. Furthermore, PDT-induced intratumoral Treg depletion did not influence adaptive immune responses in a murine influenza infection model. Thus, our results show that intratumoral Treg-targeted PDT could specifically modulate tumor microenvironments by depleting Tregs and could be used as a novel cancer immunotherapy technique. | - |
dc.language | English | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces anti-tumoral immune responses | - |
dc.type | Article | - |
dc.identifier.wosid | 000405694000062 | - |
dc.identifier.scopusid | 2-s2.0-85024369898 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 29 | - |
dc.citation.beginningpage | 47440 | - |
dc.citation.endingpage | 47453 | - |
dc.citation.publicationname | ONCOTARGET | - |
dc.identifier.doi | 10.18632/oncotarget.17663 | - |
dc.contributor.localauthor | Oh, Ji Eun | - |
dc.contributor.localauthor | Park, Ji-Ho | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.contributor.nonIdAuthor | Lee, Yun Soo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | photodynamic therapy | - |
dc.subject.keywordAuthor | immunotherapy | - |
dc.subject.keywordAuthor | Treg | - |
dc.subject.keywordAuthor | CD25 | - |
dc.subject.keywordAuthor | Chlorin e6 | - |
dc.subject.keywordPlus | CANCER-IMMUNOTHERAPY | - |
dc.subject.keywordPlus | ANTITUMOR IMMUNITY | - |
dc.subject.keywordPlus | CD4(+)CD25(+) TREG | - |
dc.subject.keywordPlus | SELF-TOLERANCE | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PHOTOSENSITIZERS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | REJECTION | - |
dc.subject.keywordPlus | EFFICACY | - |
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