Two faces of competition: target<!--?show [AQ ID=Q1]?-->-mediated reverse signalling in microRNA and mitogen-activated protein kinase regulatory networks

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Biomolecular regulatory networks are organised around hubs, which can interact with a large number of targets. These targets compete with each other for access to their common hubs, but whether the effect of this competition would be significant in magnitude and in function is not clear. In this review, the authors discuss recent in vivo studies that analysed the system level retroactive effects induced by target competition in microRNA and mitogen-activated protein kinase regulatory networks. The results of these studies suggest that downstream targets can regulate the overall state of their upstream regulators, and thus cannot be ignored in analysing biomolecular networks.
Publisher
INST ENGINEERING TECHNOLOGY-IET
Issue Date
2017-08
Language
English
Article Type
Review
Keywords

SUBSTRATE-DEPENDENT CONTROL; MODULAR CELL BIOLOGY; SHORT HAIRPIN RNAS; CAENORHABDITIS-ELEGANS; C-ELEGANS; TRANSCRIPTION FACTORS; ERK PHOSPHORYLATION; DIVERSE FUNCTIONS; CERNA HYPOTHESIS; GENE-REGULATION

Citation

IET SYSTEMS BIOLOGY, v.11, no.4, pp.105 - 113

ISSN
1751-8849
DOI
10.1049/iet-syb.2016.0042
URI
http://hdl.handle.net/10203/225198
Appears in Collection
CBE-Journal Papers(저널논문)
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