Identifying the cellular location of brain cytoplasmic 200 RNA using an RNA-recognizing antibody

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dc.contributor.authorShin, Heegwonko
dc.contributor.authorLee, Jungminko
dc.contributor.authorKim, Youngmiko
dc.contributor.authorJang, Seonghuiko
dc.contributor.authorOhn, Takbumko
dc.contributor.authorLee, Younghoonko
dc.date.accessioned2017-08-08T06:29:58Z-
dc.date.available2017-08-08T06:29:58Z-
dc.date.created2017-07-24-
dc.date.created2017-07-24-
dc.date.issued2017-06-
dc.identifier.citationBMB REPORTS, v.50, no.6, pp.318 - 322-
dc.identifier.issn1976-6696-
dc.identifier.urihttp://hdl.handle.net/10203/225158-
dc.description.abstractBrain cytoplasmic 200 RNA (BC200 RNA) is a neuron-specific non-coding RNA, implicated in the inhibition of local synaptodendritic protein synthesis, and is highly expressed in some cancer cells. Although BC200 RNA has been shown to inhibit translation in vitro, the cellular location of this inhibition is unknown. In this study, we used a BC200 RNA-recognizing antibody to identify the cellular locations of BC200 RNA in HeLa cervical carcinoma cells. We observed punctate signals in both the cytoplasm and nucleus, and further discovered that BC200 RNA co-localized with the p-body decapping enzyme, DCP1A, and the heterogeneous nuclear ribonucleoprotein E2 ( hnRNP E2). The latter is a known BC200 RNA-binding partner protein and a constituent of p-bodies. This suggests that BC200 RNA is localized to p-bodies via hnRNP E2.-
dc.languageEnglish-
dc.publisherKOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY-
dc.subjectDENDRITIC BC1 RNA-
dc.subjectBINDING-PROTEIN 2-
dc.subjectBC200 RNA-
dc.subjectTRANSLATIONAL CONTROL-
dc.subjectPOLIOVIRUS RNA-
dc.subjectBREAST-CANCER-
dc.subjectRECOGNITION-
dc.subjectEXPRESSION-
dc.subjectINITIATION-
dc.subjectMECHANISM-
dc.titleIdentifying the cellular location of brain cytoplasmic 200 RNA using an RNA-recognizing antibody-
dc.typeArticle-
dc.identifier.wosid000404811700006-
dc.identifier.scopusid2-s2.0-85022033720-
dc.type.rimsART-
dc.citation.volume50-
dc.citation.issue6-
dc.citation.beginningpage318-
dc.citation.endingpage322-
dc.citation.publicationnameBMB REPORTS-
dc.identifier.doi10.5483/BMBRep.2017.50.6.217-
dc.contributor.localauthorLee, Younghoon-
dc.contributor.nonIdAuthorOhn, Takbum-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorBC200 RNA-
dc.subject.keywordAuthorhnRNP E2-
dc.subject.keywordAuthorp-body-
dc.subject.keywordAuthorRNA-recognizing anti-body-
dc.subject.keywordPlusDENDRITIC BC1 RNA-
dc.subject.keywordPlusBINDING-PROTEIN 2-
dc.subject.keywordPlusBC200 RNA-
dc.subject.keywordPlusTRANSLATIONAL CONTROL-
dc.subject.keywordPlusPOLIOVIRUS RNA-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusRECOGNITION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusINITIATION-
dc.subject.keywordPlusMECHANISM-
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