Plastic roles of pericytes in the blood-retinal barrier

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dc.contributor.authorPark, Do Youngko
dc.contributor.authorLee, Junyeopko
dc.contributor.authorKim, Jaeryungko
dc.contributor.authorKim, Kangsanko
dc.contributor.authorHong, Seon Pyoko
dc.contributor.authorHan, Sangyeulko
dc.contributor.authorKubota, Yoshiakiko
dc.contributor.authorAugustin, Hellmut G.ko
dc.contributor.authorDing, Leiko
dc.contributor.authorKim, Jin Wooko
dc.contributor.authorKim, Hailko
dc.contributor.authorHe, Yulongko
dc.contributor.authorAdams, Ralf H.ko
dc.contributor.authorKoh, Gou Youngko
dc.date.accessioned2017-06-16T04:02:15Z-
dc.date.available2017-06-16T04:02:15Z-
dc.date.created2017-06-05-
dc.date.created2017-06-05-
dc.date.issued2017-05-
dc.identifier.citationNATURE COMMUNICATIONS, v.8-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/224092-
dc.description.abstractThe blood-retinal barrier (BRB) consists of tightly interconnected capillary endothelial cells covered with pericytes and glia, but the role of the pericytes in BRB regulation is not fully understood. Here, we show that platelet-derived growth factor (PDGF)-B/PDGF receptor beta (PDGFRb) signalling is critical in formation and maturation of BRB through active recruitment of pericytes onto growing retinal vessels. Impaired pericyte recruitment to the vessels shows multiple vascular hallmarks of diabetic retinopathy (DR) due to BRB disruption. However, PDGF-B/PDGFRb signalling is expendable for maintaining BRB integrity in adult mice. Although selective pericyte loss in stable adult retinal vessels surprisingly does not cause BRB disintegration, it sensitizes retinal vascular endothelial cells (ECs) to VEGF-A, leading to upregulation of angiopoietin-2 (Ang2) in ECs through FOXO1 activation and triggering a positive feedback that resembles the pathogenesis of DR. Accordingly, either blocking Ang2 or activating Tie2 greatly attenuates BRB breakdown, suggesting potential therapeutic approaches to reduce retinal damages upon DR progression.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectENDOTHELIAL GROWTH-FACTOR-
dc.subjectDIABETIC-RETINOPATHY-
dc.subjectGENE-EXPRESSION-
dc.subjectACTIVATES TIE2-
dc.subjectBRAIN-BARRIER-
dc.subjectIN-VIVO-
dc.subjectPDGF-B-
dc.subjectANGIOPOIETIN-2-
dc.subjectANGIOGENESIS-
dc.subjectCELLS-
dc.titlePlastic roles of pericytes in the blood-retinal barrier-
dc.typeArticle-
dc.identifier.wosid000401405300001-
dc.identifier.scopusid2-s2.0-85019406431-
dc.type.rimsART-
dc.citation.volume8-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/ncomms15296-
dc.contributor.localauthorKim, Jin Woo-
dc.contributor.localauthorKim, Hail-
dc.contributor.localauthorKoh, Gou Young-
dc.contributor.nonIdAuthorKim, Kangsan-
dc.contributor.nonIdAuthorHan, Sangyeul-
dc.contributor.nonIdAuthorKubota, Yoshiaki-
dc.contributor.nonIdAuthorAugustin, Hellmut G.-
dc.contributor.nonIdAuthorDing, Lei-
dc.contributor.nonIdAuthorHe, Yulong-
dc.contributor.nonIdAuthorAdams, Ralf H.-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusENDOTHELIAL GROWTH-FACTOR-
dc.subject.keywordPlusDIABETIC-RETINOPATHY-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusACTIVATES TIE2-
dc.subject.keywordPlusBRAIN-BARRIER-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusPDGF-B-
dc.subject.keywordPlusANGIOPOIETIN-2-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusCELLS-
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