The paper derives saddlepoint expansions for conditional expectations in the form of E[(X) over bar vertical bar(Y) over bar = a] and E[(X) over bar vertical bar(Y) over bar >= a] for the sample mean of a continuous random vector (X, Y-T) whose joint moment generating function is available. Theses conditional expectations frequently appear in various applications, particularly in quantitative finance and risk management. Using the newly developed saddlepoint expansions, we propose fast and accurate methods to compute the sensitivities of risk measures such as value-at-risk and conditional value-at-risk, and the sensitivities of financial options with respect to a market parameter. Numerical studies are provided for the accuracy verification of the new approximations.