Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition

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Synaptic inhibition counterbalances excitation, but it is not known what constitutes optimal inhibition. We previously proposed that perfect balance is achieved when the peak of an excitatory postsynaptic potential (EPSP) is exactly at spike threshold, so that the slightest variation in excitation determines whether a spike is generated. Using simulations, we show that the optimal inhibitory postsynaptic conductance (IPSG) increases in amplitude and decay rate as synaptic excitation increases from 1 to 800 Hz. As further proposed by theory, we show that optimal IPSG parameters can be learned through anti-Hebbian rules. Finally, we compare our theoretical optima to published experimental data from 21 types of neurons, in which rates of synaptic excitation and IPSG decay times vary by factors of about 100 (5-600 Hz) and 50 (1-50 ms), respectively. From an infinite range of possible decay times, theory predicted experimental decay times within less than a factor of 2. Across a distinct set of 15 types of neuron recorded in vivo, theory predicted the amplitude of synaptic inhibition within a factor of 1.7. Thus, the theory can explain biophysical quantities from first principles.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2017-03
Language
English
Article Type
Article
Keywords

MEDIAL SUPERIOR OLIVE; ELECTRICALLY COUPLED NEURONS; LATERAL GENICULATE-NUCLEUS; FEEDFORWARD INHIBITION; AUDITORY-CORTEX; IN-VIVO; COCHLEAR NUCLEUS; INFERIOR OLIVE; EXCITATION; CELLS

Citation

NATURE COMMUNICATIONS, v.8

ISSN
2041-1723
DOI
10.1038/ncomms14566
URI
http://hdl.handle.net/10203/222698
Appears in Collection
BiS-Journal Papers(저널논문)
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