Fabrication of chemical sensors and imaging nanoparticle for early-diagnosis using lithographic techniques & organic/inorganic hybrid structure.

Abstract

Development of early diagnosis device is very important research area for detection of early stage diseases such as cancer, diabetes, heart ischemia. Imaging (visualizing) and detecting certain tumor cell or chemical species can be categorized as early diagnosis method. Early stage detection can increase the surviv-al rate of patients, statically, 5-years survival rate of lung cancer patient can be increased from 3.5% to 85% through early stage diagnosis. However, previous diagnosis methods and devices have limitations to adapt for inside of human body and daily test, due to the expensive-cost, inconvenience of access, bulky-structure. Various lithographic techniques and organic/inorganic hybrid materials can provide flexibility/stretchability, selective chemical sensing and imaging carrier for advanced early diagnosis device fabrication. In this Ph.D thesis, we developed 3 kinds of platforms for imaging and detecting. Using SSL (Secondary Sputtering Lithog-raphy) and transfer printing method, we successfully fabricate anisotropic inorganic/organic nanoparticles for imaging agent carrier and ultra-thin stretchable heart monitoring pH sensor for prevent and figure out the mechanism and behavior of heart ischemia. By hybridizing organic/inorganic materials with thiol-conjugation reaction on MoS2 (Molybdenum Disulfides), we obtain the selective and sensitive VOCs (Volatile Organic Compounds) gas sensor. These advanced imaging and detecting device will be used for visualization and therapy of cancer tumor and to increase the sensitivity of early diagnosis device.