TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

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dc.contributor.authorGao, Yongko
dc.contributor.authorYao, Tingko
dc.contributor.authorDeng, Zhuoko
dc.contributor.authorSohn, Jong Wooko
dc.contributor.authorSun, Jiako
dc.contributor.authorHuang, Yiruko
dc.contributor.authorKong, Xingxingko
dc.contributor.authorYu, Kai-jiangko
dc.contributor.authorWang, Rui-taoko
dc.contributor.authorChen, Hongko
dc.contributor.authorGuo, Hongboko
dc.contributor.authorYan, Jianqunko
dc.contributor.authorCunningham, Kathryn A.ko
dc.contributor.authorChang, Yongshengko
dc.contributor.authorLiu, Tieminko
dc.contributor.authorWilliams, Kevin W.ko
dc.date.accessioned2017-03-28T06:53:26Z-
dc.date.available2017-03-28T06:53:26Z-
dc.date.created2017-02-03-
dc.date.created2017-02-03-
dc.date.issued2017-01-
dc.identifier.citationCELL REPORTS, v.18, no.3, pp.583 - 592-
dc.identifier.issn2211-1247-
dc.identifier.urihttp://hdl.handle.net/10203/220920-
dc.description.abstractThe molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is sufficient to decrease energy expenditure and increase food intake resulting in elevated body weight. Deficiency of Trpc5 subunits in Pomc neurons is also sufficient to block the anorexigenic effects of leptin and serotonin 2C receptor (Ht2Cr) agonists. The loss of acute anorexigenic effects of these receptors is concomitant with a blunted electrophysiological response to both leptin and Ht2Cr agonists in arcuate Pomc neurons. We also demonstrate that the Ht2Cr agonist lorcaserin-induced improvements in glucose and insulin tolerance are blocked by TrpC5 deficiency in Pomc neurons. Together, our results link TrpC5 subunits in the brain with leptinand serotonin 2C receptor-dependent changes in neuronal activity, as well as energy balance, feeding behavior, and glucose metabolism.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.subjectHYPOTHALAMIC PROOPIOMELANOCORTIN NEURONS-
dc.subjectREGULATES GLUCOSE-HOMEOSTASIS-
dc.subjectARCUATE NUCLEUS-
dc.subjectENERGY-BALANCE-
dc.subjectAGRP NEURONS-
dc.subjectINSULIN SENSITIVITY-
dc.subjectFEEDING CIRCUITS-
dc.subjectNEUROPEPTIDE-Y-
dc.subjectD-FENFLURAMINE-
dc.subjectBODY-WEIGHT-
dc.titleTrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons-
dc.typeArticle-
dc.identifier.wosid000396470600001-
dc.identifier.scopusid2-s2.0-85009742309-
dc.type.rimsART-
dc.citation.volume18-
dc.citation.issue3-
dc.citation.beginningpage583-
dc.citation.endingpage592-
dc.citation.publicationnameCELL REPORTS-
dc.identifier.doi10.1016/j.celrep.2016.12.072-
dc.contributor.localauthorSohn, Jong Woo-
dc.contributor.nonIdAuthorGao, Yong-
dc.contributor.nonIdAuthorYao, Ting-
dc.contributor.nonIdAuthorDeng, Zhuo-
dc.contributor.nonIdAuthorSun, Jia-
dc.contributor.nonIdAuthorHuang, Yiru-
dc.contributor.nonIdAuthorKong, Xingxing-
dc.contributor.nonIdAuthorYu, Kai-jiang-
dc.contributor.nonIdAuthorWang, Rui-tao-
dc.contributor.nonIdAuthorChen, Hong-
dc.contributor.nonIdAuthorGuo, Hongbo-
dc.contributor.nonIdAuthorYan, Jianqun-
dc.contributor.nonIdAuthorCunningham, Kathryn A.-
dc.contributor.nonIdAuthorChang, Yongsheng-
dc.contributor.nonIdAuthorLiu, Tiemin-
dc.contributor.nonIdAuthorWilliams, Kevin W.-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusHYPOTHALAMIC PROOPIOMELANOCORTIN NEURONS-
dc.subject.keywordPlusREGULATES GLUCOSE-HOMEOSTASIS-
dc.subject.keywordPlusARCUATE NUCLEUS-
dc.subject.keywordPlusENERGY-BALANCE-
dc.subject.keywordPlusAGRP NEURONS-
dc.subject.keywordPlusINSULIN SENSITIVITY-
dc.subject.keywordPlusFEEDING CIRCUITS-
dc.subject.keywordPlusNEUROPEPTIDE-Y-
dc.subject.keywordPlusD-FENFLURAMINE-
dc.subject.keywordPlusBODY-WEIGHT-
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