DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Seon Pyo | ko |
dc.contributor.author | Song, Sukhyun | ko |
dc.contributor.author | Cho, Sung Woo | ko |
dc.contributor.author | Lee, Seungjoo | ko |
dc.contributor.author | Koh, Bong Ihn | ko |
dc.contributor.author | Bae, Hosung | ko |
dc.contributor.author | Kim, Kyun Hoo | ko |
dc.contributor.author | Park, Jin Sung | ko |
dc.contributor.author | Do, Hyo Sang | ko |
dc.contributor.author | Im, Ilkyun | ko |
dc.contributor.author | Heo, Hye Jin | ko |
dc.contributor.author | Ko, Tae Hee | ko |
dc.contributor.author | Park, Jae-Hyeong | ko |
dc.contributor.author | Youm, Jae Boum | ko |
dc.contributor.author | Kim, Seong-Jin | ko |
dc.contributor.author | Kim, In-June | ko |
dc.contributor.author | Han, Jin | ko |
dc.contributor.author | Han, Yong-Mahn | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2017-03-28T06:50:39Z | - |
dc.date.available | 2017-03-28T06:50:39Z | - |
dc.date.created | 2017-03-02 | - |
dc.date.created | 2017-03-02 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.7 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/220869 | - |
dc.description.abstract | Isolating actively proliferating cardioblasts is the first crucial step for cardiac regeneration through cell implantation. However, the origin and identity of putative cardioblasts are still unclear. Here, we uncover a novel class of cardiac lineage cells, PDGFR alpha(+) Flk1(-) cardioblasts (PCBs), from mouse and human pluripotent stem cells induced using CsAYTE, a combination of the small molecules Cyclosporin A, the rho-associated coiled-coil kinase inhibitor Y27632, the antioxidant Trolox, and the ALK5 inhibitor EW7197. This novel population of actively proliferating cells is cardiac lineage-committed but in a morphologically and functionally immature state compared to mature cardiomyocytes. Most important, most of CsAYTE-induced PCBs spontaneously differentiated into functional alpha MHC+ cardiomyocytes (M+ CMs) and could be a potential cellular resource for cardiac regeneration. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CARDIOVASCULAR PROGENITOR CELLS | - |
dc.subject | CARDIAC PROGENITORS | - |
dc.subject | PRECURSOR CELLS | - |
dc.subject | SMOOTH-MUSCLE | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | CARDIOMYOCYTE | - |
dc.subject | LINEAGE | - |
dc.subject | MULTIPOTENT | - |
dc.subject | MOUSE | - |
dc.subject | HEART | - |
dc.title | Generation of PDGFR alpha(+) Cardioblasts from Pluripotent Stem Cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000393370400001 | - |
dc.identifier.scopusid | 2-s2.0-85011797683 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/srep41840 | - |
dc.contributor.localauthor | Kim, In-June | - |
dc.contributor.localauthor | Han, Yong-Mahn | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Song, Sukhyun | - |
dc.contributor.nonIdAuthor | Koh, Bong Ihn | - |
dc.contributor.nonIdAuthor | Heo, Hye Jin | - |
dc.contributor.nonIdAuthor | Ko, Tae Hee | - |
dc.contributor.nonIdAuthor | Park, Jae-Hyeong | - |
dc.contributor.nonIdAuthor | Youm, Jae Boum | - |
dc.contributor.nonIdAuthor | Kim, Seong-Jin | - |
dc.contributor.nonIdAuthor | Han, Jin | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CARDIOVASCULAR PROGENITOR CELLS | - |
dc.subject.keywordPlus | CARDIAC PROGENITORS | - |
dc.subject.keywordPlus | PRECURSOR CELLS | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | CARDIOMYOCYTE | - |
dc.subject.keywordPlus | LINEAGE | - |
dc.subject.keywordPlus | MULTIPOTENT | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | HEART | - |
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