Generation of PDGFR alpha(+) Cardioblasts from Pluripotent Stem Cells

Cited 9 time in webofscience Cited 0 time in scopus
  • Hit : 1169
  • Download : 464
DC FieldValueLanguage
dc.contributor.authorHong, Seon Pyoko
dc.contributor.authorSong, Sukhyunko
dc.contributor.authorCho, Sung Wooko
dc.contributor.authorLee, Seungjooko
dc.contributor.authorKoh, Bong Ihnko
dc.contributor.authorBae, Hosungko
dc.contributor.authorKim, Kyun Hooko
dc.contributor.authorPark, Jin Sungko
dc.contributor.authorDo, Hyo Sangko
dc.contributor.authorIm, Ilkyunko
dc.contributor.authorHeo, Hye Jinko
dc.contributor.authorKo, Tae Heeko
dc.contributor.authorPark, Jae-Hyeongko
dc.contributor.authorYoum, Jae Boumko
dc.contributor.authorKim, Seong-Jinko
dc.contributor.authorKim, In-Juneko
dc.contributor.authorHan, Jinko
dc.contributor.authorHan, Yong-Mahnko
dc.contributor.authorKoh, Gou Youngko
dc.date.accessioned2017-03-28T06:50:39Z-
dc.date.available2017-03-28T06:50:39Z-
dc.date.created2017-03-02-
dc.date.created2017-03-02-
dc.date.issued2017-02-
dc.identifier.citationSCIENTIFIC REPORTS, v.7-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10203/220869-
dc.description.abstractIsolating actively proliferating cardioblasts is the first crucial step for cardiac regeneration through cell implantation. However, the origin and identity of putative cardioblasts are still unclear. Here, we uncover a novel class of cardiac lineage cells, PDGFR alpha(+) Flk1(-) cardioblasts (PCBs), from mouse and human pluripotent stem cells induced using CsAYTE, a combination of the small molecules Cyclosporin A, the rho-associated coiled-coil kinase inhibitor Y27632, the antioxidant Trolox, and the ALK5 inhibitor EW7197. This novel population of actively proliferating cells is cardiac lineage-committed but in a morphologically and functionally immature state compared to mature cardiomyocytes. Most important, most of CsAYTE-induced PCBs spontaneously differentiated into functional alpha MHC+ cardiomyocytes (M+ CMs) and could be a potential cellular resource for cardiac regeneration.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectCARDIOVASCULAR PROGENITOR CELLS-
dc.subjectCARDIAC PROGENITORS-
dc.subjectPRECURSOR CELLS-
dc.subjectSMOOTH-MUSCLE-
dc.subjectDIFFERENTIATION-
dc.subjectCARDIOMYOCYTE-
dc.subjectLINEAGE-
dc.subjectMULTIPOTENT-
dc.subjectMOUSE-
dc.subjectHEART-
dc.titleGeneration of PDGFR alpha(+) Cardioblasts from Pluripotent Stem Cells-
dc.typeArticle-
dc.identifier.wosid000393370400001-
dc.identifier.scopusid2-s2.0-85011797683-
dc.type.rimsART-
dc.citation.volume7-
dc.citation.publicationnameSCIENTIFIC REPORTS-
dc.identifier.doi10.1038/srep41840-
dc.contributor.localauthorKim, In-June-
dc.contributor.localauthorHan, Yong-Mahn-
dc.contributor.localauthorKoh, Gou Young-
dc.contributor.nonIdAuthorSong, Sukhyun-
dc.contributor.nonIdAuthorKoh, Bong Ihn-
dc.contributor.nonIdAuthorHeo, Hye Jin-
dc.contributor.nonIdAuthorKo, Tae Hee-
dc.contributor.nonIdAuthorPark, Jae-Hyeong-
dc.contributor.nonIdAuthorYoum, Jae Boum-
dc.contributor.nonIdAuthorKim, Seong-Jin-
dc.contributor.nonIdAuthorHan, Jin-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCARDIOVASCULAR PROGENITOR CELLS-
dc.subject.keywordPlusCARDIAC PROGENITORS-
dc.subject.keywordPlusPRECURSOR CELLS-
dc.subject.keywordPlusSMOOTH-MUSCLE-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusCARDIOMYOCYTE-
dc.subject.keywordPlusLINEAGE-
dc.subject.keywordPlusMULTIPOTENT-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusHEART-
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 9 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0