DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jun, Yong-Woo | ko |
dc.contributor.author | Lee, Seung-Hee | ko |
dc.contributor.author | Shim, Jaehoon | ko |
dc.contributor.author | Lee, Jin-A | ko |
dc.contributor.author | Lim, Chae-Seok | ko |
dc.contributor.author | Kaang, Bong-Kiun | ko |
dc.contributor.author | Jang, Deok-Jin | ko |
dc.date.accessioned | 2017-01-23T02:50:32Z | - |
dc.date.available | 2017-01-23T02:50:32Z | - |
dc.date.created | 2017-01-04 | - |
dc.date.created | 2017-01-04 | - |
dc.date.created | 2017-01-04 | - |
dc.date.created | 2017-01-04 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.citation | JOURNAL OF NEUROCHEMISTRY, v.139, no.6, pp.1102 - 1112 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | http://hdl.handle.net/10203/220146 | - |
dc.description.abstract | Cytohesin family proteins act as guanine nucleotide exchange factors (GEFs) for the ADP-ribosylation factor family of small GTP-binding proteins. Aplysia Sec7 (ApSec7), a member of the cytohesin family in Aplysia, plays key roles in neurite outgrowth in Aplysia neurons. Although ApSec7 has a conserved coiled-coil (CC) domain, its role was not clear. In this study, we found that the CC domain of ApSec7 and ARNO/cytohesin 2 are involved in homodimer formation, leading to efficient plasma membrane targeting of ApSec7 and ARNO/cytohesin 2 in HEK293T cells. Therefore, deletion of the CC domain of ApSec7 and ARNO/cytohesin 2 may result in a loss of dimerization and reduce plasma membrane localization. In addition, the CC domains of ApSec7 and ARNO/cytohesin 2 have partially or fully CRM1-dependent nuclear export signals, respectively. Taken together, our results suggest that the CC domain of cytohesin family proteins, including ApSec7 and ARNO/cytohesin 2, has dual roles in intracellular targeting: increased plasma membrane targeting through homodimer formation and nuclear exclusion through either a CRM1-dependent or a CRM1-independent pathway. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | NUCLEOTIDE EXCHANGE FACTORS | - |
dc.subject | CYTOHESIN/ARNO FAMILY | - |
dc.subject | FACTORS INTERACTS | - |
dc.subject | LOCALIZATION | - |
dc.subject | SIGNALS | - |
dc.subject | BINDING | - |
dc.subject | ASSOCIATION | - |
dc.subject | EXPRESSION | - |
dc.subject | SEQUENCE | - |
dc.subject | DATABASE | - |
dc.title | Dual roles of the N-terminal coiled-coil domain of an Aplysia sec7 protein: homodimer formation and nuclear export | - |
dc.type | Article | - |
dc.identifier.wosid | 000393038700012 | - |
dc.identifier.scopusid | 2-s2.0-85006483389 | - |
dc.type.rims | ART | - |
dc.citation.volume | 139 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1102 | - |
dc.citation.endingpage | 1112 | - |
dc.citation.publicationname | JOURNAL OF NEUROCHEMISTRY | - |
dc.identifier.doi | 10.1111/jnc.13875 | - |
dc.contributor.localauthor | Lee, Seung-Hee | - |
dc.contributor.nonIdAuthor | Jun, Yong-Woo | - |
dc.contributor.nonIdAuthor | Shim, Jaehoon | - |
dc.contributor.nonIdAuthor | Lee, Jin-A | - |
dc.contributor.nonIdAuthor | Lim, Chae-Seok | - |
dc.contributor.nonIdAuthor | Kaang, Bong-Kiun | - |
dc.contributor.nonIdAuthor | Jang, Deok-Jin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | ARNO/cytohesin 2 | - |
dc.subject.keywordAuthor | coiled-coil domain | - |
dc.subject.keywordAuthor | cytohesin family | - |
dc.subject.keywordAuthor | dimerization | - |
dc.subject.keywordAuthor | nuclear export signal | - |
dc.subject.keywordAuthor | Sec7 protein | - |
dc.subject.keywordPlus | NUCLEOTIDE EXCHANGE FACTORS | - |
dc.subject.keywordPlus | CYTOHESIN/ARNO FAMILY | - |
dc.subject.keywordPlus | FACTORS INTERACTS | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | DATABASE | - |
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