Direct numerical simulation (DNS) of a turbulent channel flow with the slip boundary condition was performed to investigate the spatial characteristics of large-scale motions (LSMs) in a drag-reducing flow and the influence of LSMs on drag reduction. The slip boundary condition was applied in the streamwise direction. DNS of a channel flow with the no-slip boundary condition was also conducted for comparison. The overall mean skin-friction coefficient of the flow with the slip boundary condition was reduced by 35% relative to the flow with the no-slip condition at the same bulk Reynolds number of 10,333. The streamwise and spanwise length scales of the LSMs in the outer region are larger with the slip boundary condition than with the no-slip condition due to a large population of long LSMs. These LSMs influence the near-wall region via roll-cell motions and footprints. Although the number of total streaks decreases, a portion of the footprints increases due to the influence of the outer LSMs. The streamwise vorticities around the low-speed footprints are attenuated more than those around the high-speed footprints. The LSMs and the near-wall footprints contribute 45% of the total reduction in the skin friction coefficient, with 25% of this contribution due to low-speed LSMs. (C) 2016 Elsevier Inc. All rights reserved.