Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory

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dc.contributor.authorKim, Dohoungko
dc.contributor.authorJeong, Huijeongko
dc.contributor.authorLee, Juhyeongko
dc.contributor.authorGhim, Jeong-Wookko
dc.contributor.authorHer, Eun Silko
dc.contributor.authorLee, Seung-Heeko
dc.contributor.authorJung, Min Whanko
dc.date.accessioned2017-01-12T07:19:46Z-
dc.date.available2017-01-12T07:19:46Z-
dc.date.created2016-12-23-
dc.date.created2016-12-23-
dc.date.issued2016-11-
dc.identifier.citationNEURON, v.92, no.4, pp.902 - 915-
dc.identifier.issn0896-6273-
dc.identifier.urihttp://hdl.handle.net/10203/218310-
dc.description.abstractInhibitory interneurons are thought to play crucial roles in diverse brain functions. However, roles of different inhibitory interneuron subtypes in working memory remain unclear. We found distinct activity patterns and stimulation effects of two major interneuron subtypes, parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons, in the medial prefrontal cortex of mice performing a spatial working memory task. PV interneurons showed weak target-dependent delay-period activity and were strongly inhibited by reward. By contrast, SOM interneurons showed strong target-dependent delay-period activity, and only a subtype of them was inhibited by reward. Furthermore, optogenetic stimulation of PV and SOM interneurons preferentially suppressed discharges of putative pyramidal cells and interneurons, respectively. These results indicate different contributions of PV and SOM interneurons to prefrontal cortical circuit dynamics underlying working memory.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.subjectDELAYED ALTERNATION PERFORMANCE-
dc.subjectPREFRONTAL CORTEX-
dc.subjectCORTICAL MICROCIRCUIT-
dc.subjectUNIT-ACTIVITY-
dc.subjectINHIBITION-
dc.subjectSUBTYPES-
dc.subjectNEURONS-
dc.subjectCELLS-
dc.subjectMODEL-
dc.subjectTASK-
dc.titleDistinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory-
dc.typeArticle-
dc.identifier.wosid000388572700022-
dc.identifier.scopusid2-s2.0-84997228888-
dc.type.rimsART-
dc.citation.volume92-
dc.citation.issue4-
dc.citation.beginningpage902-
dc.citation.endingpage915-
dc.citation.publicationnameNEURON-
dc.identifier.doi10.1016/j.neuron.2016.09.023-
dc.contributor.localauthorLee, Seung-Hee-
dc.contributor.localauthorJung, Min Whan-
dc.contributor.nonIdAuthorLee, Juhyeong-
dc.contributor.nonIdAuthorGhim, Jeong-Wook-
dc.contributor.nonIdAuthorHer, Eun Sil-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusDELAYED ALTERNATION PERFORMANCE-
dc.subject.keywordPlusPREFRONTAL CORTEX-
dc.subject.keywordPlusCORTICAL MICROCIRCUIT-
dc.subject.keywordPlusUNIT-ACTIVITY-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusSUBTYPES-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlusTASK-
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