Plasma treatment effect on angiogenesis in wound healing process evaluated in vivo using angiographic optical coherence tomography

Cited 6 time in webofscience Cited 0 time in scopus
  • Hit : 318
  • Download : 0
Non-thermal atmospheric pressure plasma holds promise for promoting wound healing. However, plasma-induced angiogenesis, which is important to better understand the underlying physics of plasma treatment effect on wound healing, remains largely unknown. We therefore evaluated the effect of non-thermal plasma on angiogenesis during wound healing through longitudinal monitoring over 30 days using non-invasive angiographic optical coherence tomography imaging in vivo. We demonstrate that the plasma-treated vascular wound area of mouse ear was noticeably decreased as compared to that of control during the early days in the wound healing process. We also observed that the vascular area density was increased in the plasma affected region near the wound as compared to the plasma unaffected region. The difference in the vascular wound area and the vascular area density peaked around day 3. This indicates that the plasma treatment induced additional angiogenic effects in the wound healing process especially during the early days. This non-invasive optical angiographic approach for in vivo time-lapse imaging provides further insights into elucidating plasma-induced angiogenesis in the wound healing process and its application in the biomedical plasma evaluation. Published by AIP Publishing.
Publisher
AMER INST PHYSICS
Issue Date
2016-12
Language
English
Article Type
Article
Keywords

NITRIC-OXIDE; HIGH-SPEED; ULTRAHIGH-SPEED; CANCER-THERAPY; MICROSCOPY; OCT; REPAIR; NEEDLE

Citation

APPLIED PHYSICS LETTERS, v.109, no.23

ISSN
0003-6951
DOI
10.1063/1.4967375
URI
http://hdl.handle.net/10203/218300
Appears in Collection
ME-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 6 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0