Dehydrosulfurative C-N Cross-Coupling and Concomitant Oxidative Dehydrogenation for One-Step Synthesis of 2-Aryl(alkyl)aminopyrimidines from 3,4-Dihydropyrimidin-1H-2-thiones
A method for the synthesis of 2-aryl(alkyl)-aminopyrimidines from readily available 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) via dehydrosulfurative C-N cross coupling and concomitant oxidative dehydrogenation under a Pd/Cu catalytic system is described. This reaction protocol provides unprecedented diversity of fully substituted 2-aryl(alkyl)aminopyrimidines in a single step from a wide range of DHPMs and amine coupling partners
- Publisher
- AMER CHEMICAL SOC
- Issue Date
- 2016-10
- Language
- English
- Article Type
- Article
- Keywords
CARBON BOND FORMATION; PYRIMIDIN-2-YL SULFONATES; BIOLOGICAL-ACTIVITY; EFFICIENT APPROACH; CYCLIC THIOAMIDES; CARBOXYLIC-ACIDS; ARYL SULFIDES; BORONIC ACIDS; INHIBITORS; CONVERSION
- Citation
ORGANIC LETTERS, v.18, no.19, pp.5154 - 5157
- ISSN
- 1523-7060
- Appears in Collection
- CH-Journal Papers(저널논문)
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