Vulnerability-Based Critical Neurons, Synapses, and Pathways in the Caenorhabditis elegans Connectome

Cited 12 time in webofscience Cited 0 time in scopus
  • Hit : 441
  • Download : 577
Determining the fundamental architectural design of complex nervous systems will lead to significant medical and technological advances. Yet it remains unclear how nervous systems evolved highly efficient networks with near optimal sharing of pathways that yet produce multiple distinct behaviors to reach the organism's goals. To determine this, the nematode roundworm Caenorhabditis elegans is an attractive model system. Progress has been made in delineating the behavioral circuits of the C. elegans, however, many details are unclear, including the specific functions of every neuron and synapse, as well as the extent the behavioral circuits are separate and parallel versus integrative and serial. Network analysis provides a normative approach to help specify the network design. We investigated the vulnerability of the Caenorhabditis elegans connectome by performing computational experiments that (a) "attacked" 279 individual neurons and 2,990 weighted synaptic connections (composed of 6,393 chemical synapses and 890 electrical junctions) and (b) quantified the effects of each removal on global network properties that influence information processing. The analysis identified 12 critical neurons and 29 critical synapses for establishing fundamental network properties. These critical constituents were found to be control elements-i.e., those with the most influence over multiple underlying pathways. Additionally, the critical synapses formed into circuit-level pathways. These emergent pathways provide evidence for (a) the importance of backward locomotion, avoidance behavior, and social feeding behavior to the organism; (b) the potential roles of specific neurons whose functions have been unclear; and (c) both parallel and serial design elements in the connectome-i.e., specific evidence for a mixed architectural design
Publisher
PUBLIC LIBRARY SCIENCE
Issue Date
2016-08
Language
English
Article Type
Article
Keywords

MALE MATING-BEHAVIOR; C-ELEGANS; NERVOUS-SYSTEM; NETWORK; ORGANIZATION; CIRCUIT; INTEGRATION; ATTRACTION; DYNAMICS; CUES

Citation

PLOS COMPUTATIONAL BIOLOGY, v.12, no.8

ISSN
1553-734X
DOI
10.1371/journal.pcbi.1005084
URI
http://hdl.handle.net/10203/213800
Appears in Collection
BiS-Journal Papers(저널논문)
Files in This Item
97340.pdf(0 B)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 12 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0