DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Eunjeong | ko |
dc.contributor.author | Kim, Wan-Young | ko |
dc.contributor.author | Hur, Jeongmi | ko |
dc.contributor.author | Kim, Hanbyul | ko |
dc.contributor.author | Nam, Sun Ah | ko |
dc.contributor.author | Choi, Arum | ko |
dc.contributor.author | Kim, Yu-Mi | ko |
dc.contributor.author | Park, Sang Hee | ko |
dc.contributor.author | Chung, Chaeuk | ko |
dc.contributor.author | Kim, Jin | ko |
dc.contributor.author | Min, Soohong | ko |
dc.contributor.author | Myung, Seung-Jae | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.contributor.author | Kim, Yong Kyun | ko |
dc.date.accessioned | 2016-10-04T07:20:01Z | - |
dc.date.available | 2016-10-04T07:20:01Z | - |
dc.date.created | 2016-09-21 | - |
dc.date.created | 2016-09-21 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.6 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/213077 | - |
dc.description.abstract | Renal tubulointerstitial fibrosis (TIF) is the final pathway of various renal injuries that result in chronic kidney disease. The mammalian Hippo-Salvador signaling pathway has been implicated in the regulation of cell proliferation, cell death, tissue regeneration, and tumorigenesis. Here, we report that the Hippo-Salvador pathway plays a role in disease development in patients with TIF and in a mouse model of TIF. Mice with tubular epithelial cell (TEC)-specific deletions of Sav1 (Salvador homolog 1) exhibited aggravated renal TIF, enhanced epithelial-mesenchymal transition-like phenotypic changes, apoptosis, and proliferation after unilateral ureteral obstruction (UUO). Moreover, Sav1 depletion in TECs increased transforming growth factor (TGF)-beta and activated beta-catenin expression after UUO, which likely accounts for the abovementioned enhanced TEC fibrotic phenotype. In addition, TAZ (transcriptional coactivator with PDZ-binding motif), a major downstream effector of the Hippo pathway, was significantly activated in Sav1-knockout mice in vivo. An in vitro study showed that TAZ directly regulates TGF-beta and TGF-beta receptor II expression. Collectively, our data indicate that the Hippo-Salvador pathway plays a role in the pathogenesis of TIF and that regulating this pathway may be a therapeutic strategy for reducing TIF | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CELL SELF-RENEWAL | - |
dc.subject | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject | KIDNEY FIBROSIS | - |
dc.subject | INTERSTITIAL FIBROSIS | - |
dc.subject | TUMOR-SUPPRESSOR | - |
dc.subject | GROWTH-CONTROL | - |
dc.subject | SIZE-CONTROL | - |
dc.subject | YAP | - |
dc.subject | PROLIFERATION | - |
dc.subject | APOPTOSIS | - |
dc.title | The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis | - |
dc.type | Article | - |
dc.identifier.wosid | 000381862600001 | - |
dc.identifier.scopusid | 2-s2.0-84984604068 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/srep31931 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Seo, Eunjeong | - |
dc.contributor.nonIdAuthor | Kim, Wan-Young | - |
dc.contributor.nonIdAuthor | Nam, Sun Ah | - |
dc.contributor.nonIdAuthor | Choi, Arum | - |
dc.contributor.nonIdAuthor | Kim, Yu-Mi | - |
dc.contributor.nonIdAuthor | Park, Sang Hee | - |
dc.contributor.nonIdAuthor | Chung, Chaeuk | - |
dc.contributor.nonIdAuthor | Kim, Jin | - |
dc.contributor.nonIdAuthor | Min, Soohong | - |
dc.contributor.nonIdAuthor | Myung, Seung-Jae | - |
dc.contributor.nonIdAuthor | Kim, Yong Kyun | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CELL SELF-RENEWAL | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | KIDNEY FIBROSIS | - |
dc.subject.keywordPlus | INTERSTITIAL FIBROSIS | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | GROWTH-CONTROL | - |
dc.subject.keywordPlus | SIZE-CONTROL | - |
dc.subject.keywordPlus | YAP | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
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