DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cayirlioglu, Pelin | ko |
dc.contributor.author | Kadow, Ilona Grunwald | ko |
dc.contributor.author | Zhan, Xiaoli | ko |
dc.contributor.author | Okamura, Katsutomo | ko |
dc.contributor.author | Suh, Greg S. B. | ko |
dc.contributor.author | Gunning, Dorian | ko |
dc.contributor.author | Lai, Eric C. | ko |
dc.contributor.author | Zipursky, S. Lawrence | ko |
dc.date.accessioned | 2016-07-25T08:31:09Z | - |
dc.date.available | 2016-07-25T08:31:09Z | - |
dc.date.created | 2016-07-12 | - |
dc.date.created | 2016-07-12 | - |
dc.date.issued | 2008-02 | - |
dc.identifier.citation | SCIENCE, v.319, no.5867, pp.1256 - 1260 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10203/211915 | - |
dc.description.abstract | Carbon dioxide ( CO2) elicits different olfactory behaviors across species. In Drosophila, neurons that detect CO2 are located in the antenna, form connections in a ventral glomerulus in the antennal lobe, and mediate avoidance. By contrast, in the mosquito these neurons are in the maxillary palps ( MPs), connect to medial sites, and promote attraction. We found in Drosophila that loss of a microRNA, miR- 279, leads to formation of CO2 neurons in the MPs. miR- 279 acts through down- regulation of the transcription factor Nerfin- 1. The ectopic neurons are hybrid cells. They express CO2 receptors and form connections characteristic of CO2 neurons, while exhibiting wiring and receptor characteristics of MP olfactory receptor neurons ( ORNs). We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species- specific behaviors elicited by CO2 | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.subject | CENTRAL PROJECTIONS | - |
dc.subject | RECEPTOR NEURONS | - |
dc.subject | AEDES-AEGYPTI | - |
dc.subject | DROSOPHILA | - |
dc.subject | MAXILLARY | - |
dc.subject | SENSILLA | - |
dc.subject | MOTHS | - |
dc.title | Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems | - |
dc.type | Article | - |
dc.identifier.wosid | 000253530600048 | - |
dc.identifier.scopusid | 2-s2.0-40049098982 | - |
dc.type.rims | ART | - |
dc.citation.volume | 319 | - |
dc.citation.issue | 5867 | - |
dc.citation.beginningpage | 1256 | - |
dc.citation.endingpage | 1260 | - |
dc.citation.publicationname | SCIENCE | - |
dc.identifier.doi | 10.1126/science.1149483 | - |
dc.contributor.localauthor | Suh, Greg S. B. | - |
dc.contributor.nonIdAuthor | Cayirlioglu, Pelin | - |
dc.contributor.nonIdAuthor | Kadow, Ilona Grunwald | - |
dc.contributor.nonIdAuthor | Zhan, Xiaoli | - |
dc.contributor.nonIdAuthor | Okamura, Katsutomo | - |
dc.contributor.nonIdAuthor | Gunning, Dorian | - |
dc.contributor.nonIdAuthor | Lai, Eric C. | - |
dc.contributor.nonIdAuthor | Zipursky, S. Lawrence | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CENTRAL PROJECTIONS | - |
dc.subject.keywordPlus | RECEPTOR NEURONS | - |
dc.subject.keywordPlus | AEDES-AEGYPTI | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | MAXILLARY | - |
dc.subject.keywordPlus | SENSILLA | - |
dc.subject.keywordPlus | MOTHS | - |
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