RTK signaling modulates the Dorsal gradient

Cited 20 time in webofscience Cited 0 time in scopus
  • Hit : 435
  • Download : 0
The dorsoventral (DV) axis of the Drosophila embryo is patterned by a nuclear gradient of the Rel family transcription factor, Dorsal (Dl), that activates or represses numerous target genes in a region-specific manner. Here, we demonstrate that signaling by receptor tyrosine kinases (RTK) reduces nuclear levels and transcriptional activity of Dl, both at the poles and in the mid-body of the embryo. These effects depend on wntD, which encodes a Dl antagonist belonging to the Wingless/Wnt family of secreted factors. Specifically, we show that, via relief of Groucho- and Capicua-mediated repression, the Torso and EGFR RTK pathways induce expression of WntD, which in turn limits Dl nuclear localization at the poles and along the DV axis. Furthermore, this RTK-dependent control of Dl is important for restricting expression of its targets in both contexts. Thus, our results reveal a new mechanism of crosstalk, whereby RTK signals modulate the spatial distribution and activity of a developmental morphogen in vivo.
Publisher
COMPANY OF BIOLOGISTS LTD
Issue Date
2012-08
Language
English
Article Type
Article
Keywords

DROSOPHILA-EMBRYO; GENE-EXPRESSION; MEDIATED REPRESSION; MORPHOGEN GRADIENTS; GROUCHO; TORSO; TWIST; PATHWAYS; CAPICUA; SNAIL

Citation

DEVELOPMENT, v.139, no.16, pp.3032 - 3039

ISSN
0950-1991
DOI
10.1242/dev.075812
URI
http://hdl.handle.net/10203/211816
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 20 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0