DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin Man | ko |
dc.contributor.author | Lee, Minji | ko |
dc.contributor.author | Kim, Nury | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.date.accessioned | 2016-07-07T06:18:17Z | - |
dc.date.available | 2016-07-07T06:18:17Z | - |
dc.date.created | 2016-06-27 | - |
dc.date.created | 2016-06-27 | - |
dc.date.created | 2016-06-27 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.113, no.21, pp.5952 - 5957 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/210006 | - |
dc.description.abstract | Cell migration is controlled by various Ca2+ signals. Local Ca2+ signals, in particular, have been identified as versatile modulators of cell migration because of their spatiotemporal diversity. However, little is known about how local Ca2+ signals coordinate between the front and rear regions in directionally migrating cells. Here, we elucidate the spatial role of local Ca2+ signals in directed cell migration through combinatorial application of an optogenetic toolkit. An optically guided cell migration approach revealed the existence of Ca2+ sparklets mediated by L-type voltage-dependent Ca2+ channels in the rear part of migrating cells. Notably, we found that this locally concentrated Ca2+ influx acts as an essential transducer in establishing a global front-to-rear increasing Ca2+ gradient. This asymmetrical Ca2+ gradient is crucial for maintaining front-rear morphological polarity by restricting spontaneous lamellipodia formation in the rear part of migrating cells. Collectively, our findings demonstrate a clear link between local Ca2+ sparklets and front-rear coordination during directed cell migration | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Optogenetic toolkit reveals the role of Ca2+ sparklets in coordinated cell migration | - |
dc.type | Article | - |
dc.identifier.wosid | 000376779900060 | - |
dc.identifier.scopusid | 2-s2.0-84969858875 | - |
dc.type.rims | ART | - |
dc.citation.volume | 113 | - |
dc.citation.issue | 21 | - |
dc.citation.beginningpage | 5952 | - |
dc.citation.endingpage | 5957 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1518412113 | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.nonIdAuthor | Kim, Jin Man | - |
dc.contributor.nonIdAuthor | Kim, Nury | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | optogenetics | - |
dc.subject.keywordAuthor | cell migration | - |
dc.subject.keywordAuthor | calcium signaling | - |
dc.subject.keywordAuthor | cell polarity | - |
dc.subject.keywordAuthor | actin cytoskeleton | - |
dc.subject.keywordPlus | PIG VENTRICULAR MYOCYTES | - |
dc.subject.keywordPlus | GATED CALCIUM-CHANNELS | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | SPATIOTEMPORAL CONTROL | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | BLUE-LIGHT | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | ACTIN | - |
dc.subject.keywordPlus | CONTRACTION | - |
dc.subject.keywordPlus | INDICATORS | - |
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