Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies

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The spontaneous cerebral hemodynamic fluctuations observed during the resting state have been frequently visualized using functional magnetic resonance imaging (rsfMRI). However, the neuronal populations and neuroelectric characteristics underlying the functional connectivity of cerebrohemodynamic activities are poorly understood. We investigated the characteristics of bi-hemispheric functional connectivity via electrophysiology and rsfMRI in the primary sensory cortex of rats anesthetized by alpha-chloralose. Unlike the evoked responses, the spontaneous electrophysiological activity was concentrated in the infragranular layers and could be classified into subtypes with distinctive current sources and sinks. Both neuroelectric and rsfMRI signals were interhemispherically correlated in a layer-specific manner, suggesting that there are independent neural inputs to infragranular and granular/supragranular layers. The majority of spontaneous electrophysiological activities were bilaterally paired with delays of up to similar to 50 ms between each pair. The variable interhemispheric delay implies the involvement of indirect, multi-neural pathways. Our findings demonstrated the diverse activity patterns of layer-specific electrophysiological substrates and suggest the recruitment of multiple, non-specific brain regions in construction of interhemispheric functional connectivity.
Publisher
SPRINGER HEIDELBERG
Issue Date
2016-06
Language
English
Article Type
Article
Keywords

INDEPENDENT COMPONENT ANALYSIS; LOW-FREQUENCY FLUCTUATIONS; MONKEY VISUAL-CORTEX; CORPUS-CALLOSUM; BARREL CORTEX; BOLD FMRI; LAMINAR SPECIFICITY; BRAIN ACTIVITY; MRI SIGNAL; DYNAMICS

Citation

BRAIN STRUCTURE & FUNCTION, v.221, no.5, pp.2801 - 2815

ISSN
1863-2653
DOI
10.1007/s00429-015-1073-0
URI
http://hdl.handle.net/10203/209832
Appears in Collection
BiS-Journal Papers(저널논문)
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