Smartphone-Based Fluorescent Diagnostic System for Highly Pathogenic H5N1 Viruses

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dc.contributor.authorYeo, Seon-Juko
dc.contributor.authorChoi, Kyunghanko
dc.contributor.authorCuc, Bui Thiko
dc.contributor.authorHong, Nguyen Ngocko
dc.contributor.authorBao, Duong Tuanko
dc.contributor.authorNgoc, Nguyen Minhko
dc.contributor.authorLe, Mai Quynhko
dc.contributor.authorHang, Nguyen Le Khanhko
dc.contributor.authorThach, Nguyen Coko
dc.contributor.authorMallik, Shyam Kumarko
dc.contributor.authorKim, Hak Sungko
dc.contributor.authorChong, Chom-Kyuko
dc.contributor.authorChoi, Hak Sooko
dc.contributor.authorSung, Haan Wooko
dc.contributor.authorYu, Kyoungsikko
dc.contributor.authorPark, Hyunko
dc.date.accessioned2016-07-07T04:58:38Z-
dc.date.available2016-07-07T04:58:38Z-
dc.date.created2016-04-05-
dc.date.created2016-04-05-
dc.date.created2016-04-05-
dc.date.issued2016-02-
dc.identifier.citationTHERANOSTICS, v.6, no.2, pp.231 - 242-
dc.identifier.issn1838-7640-
dc.identifier.urihttp://hdl.handle.net/10203/209756-
dc.description.abstractField diagnostic tools for avian influenza (AI) are indispensable for the prevention and controlled management of highly pathogenic AI-related diseases. More accurate, faster and networked on-site monitoring is demanded to detect such AI viruses with high sensitivity as well as to maintain up-to-date information about their geographical transmission. In this work, we assessed the clinical and field-level performance of a smartphone-based fluorescent diagnostic device with an efficient reflective light collection module using a coumarin-derived dendrimer-based fluorescent lateral flow immunoassay. By application of an optimized bioconjugate, a smartphone-based diagnostic device had a two-fold higher detectability as compared to that of the table-top fluorescence strip reader for three different AI subtypes (H5N3, H7N1, and H9N2). Additionally, in a clinical study of H5N1-confirmed patients, the smartphone-based diagnostic device showed a sensitivity of 96.55% (28/29)[ 95% confidence interval (CI): 82.24 to 99.91] and a specificity of 98.55% (68/69) (95% CI: 92.19 to 99.96). The measurement results from the distributed individual smartphones were wirelessly transmitted via short messaging service and collected by a centralized database system for further information processing and data mining. Smartphone-based diagnosis provided highly sensitive measurement results for H5N1 detection within 15 minutes. Because of its high sensitivity, portability and automatic reporting feature, the proposed device will enable agile identification of patients and efficient control of AI dissemination.-
dc.languageEnglish-
dc.publisherIVYSPRING INT PUBL-
dc.titleSmartphone-Based Fluorescent Diagnostic System for Highly Pathogenic H5N1 Viruses-
dc.typeArticle-
dc.identifier.wosid000371806900007-
dc.identifier.scopusid2-s2.0-84954508565-
dc.type.rimsART-
dc.citation.volume6-
dc.citation.issue2-
dc.citation.beginningpage231-
dc.citation.endingpage242-
dc.citation.publicationnameTHERANOSTICS-
dc.identifier.doi10.7150/thno.14023-
dc.contributor.localauthorYu, Kyoungsik-
dc.contributor.nonIdAuthorYeo, Seon-Ju-
dc.contributor.nonIdAuthorCuc, Bui Thi-
dc.contributor.nonIdAuthorHong, Nguyen Ngoc-
dc.contributor.nonIdAuthorBao, Duong Tuan-
dc.contributor.nonIdAuthorNgoc, Nguyen Minh-
dc.contributor.nonIdAuthorLe, Mai Quynh-
dc.contributor.nonIdAuthorHang, Nguyen Le Khanh-
dc.contributor.nonIdAuthorThach, Nguyen Co-
dc.contributor.nonIdAuthorMallik, Shyam Kumar-
dc.contributor.nonIdAuthorKim, Hak Sung-
dc.contributor.nonIdAuthorChong, Chom-Kyu-
dc.contributor.nonIdAuthorChoi, Hak Soo-
dc.contributor.nonIdAuthorSung, Haan Woo-
dc.contributor.nonIdAuthorPark, Hyun-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorhighly pathogenic H5N1 influenza virus-
dc.subject.keywordAuthorsmartphone-based fluorescent diagnostic device-
dc.subject.keywordAuthorfluorescence-based immunochromatographic strip test-
dc.subject.keywordAuthorcoumarin-derived dendrimer-
dc.subject.keywordAuthorfield application-
dc.subject.keywordPlusAVIAN INFLUENZA H5N1-
dc.subject.keywordPlusA H5N1-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusVIETNAM-
dc.subject.keywordPlusDEVICE-
dc.subject.keywordPlusH9N2-
dc.subject.keywordPlusASIA-
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