DC Field | Value | Language |
---|---|---|
dc.contributor.author | Le, Thao Phuong | ko |
dc.contributor.author | Voung, Linh Thuong | ko |
dc.contributor.author | Kim, Ah Ram | ko |
dc.contributor.author | Hsu, Ya-Chieh | ko |
dc.contributor.author | Choi, Kwang-Wook | ko |
dc.date.accessioned | 2016-07-05T08:18:43Z | - |
dc.date.available | 2016-07-05T08:18:43Z | - |
dc.date.created | 2016-05-31 | - |
dc.date.created | 2016-05-31 | - |
dc.date.created | 2016-05-31 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.7 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/209319 | - |
dc.description.abstract | 14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally controlled tumour protein (Tctp) and Rheb GTPase. Single knockdown of 14-3-3 epsilon or 14-3-3 zeta isoform does not show obvious defects in organ development but causes synergistic genetic interaction with Tctp and Rheb to impair tissue growth. 14-3-3 proteins physically interact with Tctp and Rheb. Knockdown of both 14-3-3 isoforms abolishes the binding between Tctp and Rheb, disrupting organ development. Depletion of 14-3-3s also reduces the level of phosphorylated S6 kinase, phosphorylated Thor/4E-BP and cyclin E (CycE). Growth defects from knockdown of 14-3-3 and Tctp are suppressed by CycE overexpression. This study suggests a novel mechanism of Tor regulation mediated by 14-3-3 interaction with Tctp and Rheb | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | 14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila | - |
dc.type | Article | - |
dc.identifier.wosid | 000375495400001 | - |
dc.identifier.scopusid | 2-s2.0-84967318081 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms11501 | - |
dc.contributor.localauthor | Choi, Kwang-Wook | - |
dc.contributor.nonIdAuthor | Hsu, Ya-Chieh | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CONTROLLED TUMOR PROTEIN | - |
dc.subject.keywordPlus | MEDIATED PHOSPHORYLATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CELL-GROWTH | - |
dc.subject.keywordPlus | TSC2 | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | GTPASE | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordPlus | 14-3-3-PROTEINS | - |
dc.subject.keywordPlus | ACTIVATION | - |
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