Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo

Cited 10 time in webofscience Cited 0 time in scopus
  • Hit : 386
  • Download : 598
Terminal regions of the Drosophila embryo are patterned by the localized activation of Mitogen Activated Protein Kinase (MAPK), which induces zygotic genes through relief of their repression by transcriptional repressor Capicua. The levels of MAPK activation at the anterior and posterior termini are close to each other, but the expression patterns of MAPK-target genes, such as zerknullt (zen) and tailless (tll), display strong anterior-posterior (AP) asymmetry. This region-specific response to MAPK activation provides a clear example of context-dependent interpretation of inductive signaling, a common developmental effect that remains poorly understood. In the past, the AP asymmetry of zen expression was attributed to a mechanism that depends on MAPK substrate competition. We present data suggesting that the asymmetric expression of tll is generated by a different mechanism, based on feedforward control and multiple enhancers of the tll gene. A simple mathematical model of this mechanism correctly predicts how the wild-type expression pattern of tll changes in mutants affecting the anterior, dorsoventral, and terminal patterning systems and some of their direct targets.
Publisher
AMER INST PHYSICS
Issue Date
2013-06
Language
English
Article Type
Article
Keywords

TAILLESS EXPRESSION; REGULATORY ELEMENTS; DORSAL MORPHOGEN; GENE-EXPRESSION; RECEPTOR; REPRESSOR; GRADIENT; BINDING; SYSTEM; MELANOGASTER

Citation

CHAOS, v.23, no.2

ISSN
1054-1500
DOI
10.1063/1.4808157
URI
http://hdl.handle.net/10203/209191
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
000321146500038.pdf(4.35 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 10 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0