Protein conjugation with genetically encoded unnatural amino acids

Cited 203 time in webofscience Cited 191 time in scopus
  • Hit : 407
  • Download : 0
The site-specific incorporation of unnatural amino acids with orthogonal chemical reactivity into proteins enables the synthesis of structurally defined protein conjugates. Amino acids containing ketone, azide, alkyne, alkene, and tetrazine side chains can be genetically encoded in response to nonsense and frameshift codons. These bio-orthogonal chemical handles allow precise control over the site and stoichiometry of conjugation, and have enabled medicinal chemistry-like optimization of the physical and biological properties of protein conjugates, especially the next-generation protein therapeutics.
Publisher
ELSEVIER SCI LTD
Issue Date
2013-06
Language
English
Article Type
Review
Keywords

SITE-SPECIFIC INCORPORATION; TRANSFER-RNA SYNTHETASE; ESCHERICHIA-COLI; BISPECIFIC ANTIBODIES; MAMMALIAN-CELLS; RECOMBINANT PROTEINS; TRANS-CYCLOOCTENES; CLICK CHEMISTRY; CANCER-THERAPY; CODE

Citation

CURRENT OPINION IN CHEMICAL BIOLOGY, v.17, no.3, pp.412 - 419

ISSN
1367-5931
DOI
10.1016/j.cbpa.2013.04.017
URI
http://hdl.handle.net/10203/209136
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 203 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0