Black Phosphorus (BP) Nanodots for Potential Biomedical Applications

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Recently, the appeal of 2D black phosphorus (BP) has been rising due to its unique optical and electronic properties with a tunable band gap (approximate to 0.3-1.5 eV). While numerous research efforts have recently been devoted to nano-and optoelectronic applications of BP, no attention has been paid to promising medical applications. In this article, the preparation of BP-nanodots of a few nm to <20 nm with an average diameter of approximate to 10 nm and height of approximate to 8.7 nm is reported by a modified ultrasonication-assisted solution method. Stable formation of nontoxic phosphates and phosphonates from BP crystals with exposure in water or air is observed. As for the BP-nanodot crystals' stability (ionization and persistence of fluorescent intensity) in aqueous solution, after 10 d, approximate to 80% at 1.5 mg mL(-1) are degraded (i.e., ionized) in phosphate buffered saline. They showed no or little cytotoxic cell-viability effects in vitro involving blue-and green-fluorescence cell imaging. Thus, BP-nanodots can be considered a promising agent for drug delivery or cellular tracking systems
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2016-01
Language
English
Article Type
Article
Citation

SMALL, v.12, no.2, pp.214 - 219

ISSN
1613-6810
DOI
10.1002/smll.201502756
URI
http://hdl.handle.net/10203/208971
Appears in Collection
CBE-Journal Papers(저널논문)
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