Drosophila Schipl Links Expanded and Tao-1 to Regulate Hippo Signaling

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Regulation of organ size is essential in animal development, and Hippo (Hpo) signaling is a major conserved mechanism for controlling organ growth. In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki). Expanded (Ex) is a regulator of the Hpo activity, but how they are linked is unknown. Here, we show that Schip1, a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. Ex is required for apical localization of Schip1 in imaginal discs. Schipl is necessary for promoting membrane localization and phosphorylation of Hpo by recruiting the Hpo kinase Tao-1. Taking these findings together, we conclude that Schipl directly links Ex to Hpo signaling by recruiting Tao-1. This study provides insights into the mechanism of Tao-1 regulation and a potential growth control function for SCHIP1 in mammals.
Publisher
CELL PRESS
Issue Date
2016-03
Language
English
Article Type
Article
Keywords

TUMOR-SUPPRESSOR PATHWAY; ORGAN SIZE CONTROL; CELL-CYCLE EXIT; TRANSMEMBRANE PROTEIN CRUMBS; CONTROLS TISSUE-GROWTH; PROMOTES APOPTOSIS; IN-VIVO; YORKIE PHOSPHORYLATION; PROLIFERATION ARREST; TEAD/TEF FAMILY

Citation

DEVELOPMENTAL CELL, v.36, no.5, pp.511 - 524

ISSN
1534-5807
DOI
10.1016/j.devcel.2016.02.004
URI
http://hdl.handle.net/10203/208330
Appears in Collection
BS-Journal Papers(저널논문)
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