Protective efficacy of Streptococcus iniae derived enolase against Streptococcal infection in a zebrafish model

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Enolase (ENO) is one of the surface-exposed proteins of Streptococcus iniae, which previously had been identified as a plasminogen-binding protein. In this study, ENO was evaluated to induce cross-protective immunity against S. iniae and Streptococcus parauberis which are major pathogens causing streptococcosis in fish. Immunoblot analysis shows that S. iniae recombinant ENO (rENO) produced in Escherichia coli was cross-reactive with antisera against S. iniae, and S. parauberis serotype land II. In the challenge experiment of streptococcal infection after vaccination in zebrafish, rENO elicited a similar protection with a whole cell bacterin against S. iniae and S. parauberis, which suggests its feasibility as an efficient vaccine against streptococcosis.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2016-02
Language
English
Article Type
Article
Citation

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v.170, pp.25 - 29

ISSN
0165-2427
DOI
10.1016/j.vetimm.2016.01.004
URI
http://hdl.handle.net/10203/207960
Appears in Collection
CBE-Journal Papers(저널논문)
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