Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa

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dc.contributor.authorOh, Ji Eunko
dc.contributor.authorLee, Heung Kyuko
dc.date.accessioned2016-05-16T08:44:42Z-
dc.date.available2016-05-16T08:44:42Z-
dc.date.created2016-02-22-
dc.date.created2016-02-22-
dc.date.created2016-02-22-
dc.date.created2016-02-22-
dc.date.created2016-02-22-
dc.date.issued2016-02-
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.196-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10203/207425-
dc.description.abstractCommensal microbiota are well known to play an important role in antiviral immunity by providing immune inductive signals; however, the consequence of dysbiosis on antiviral immunity remains unclear. We demonstrate that dysbiosis caused by oral antibiotic treatment directly impairs antiviral immunity following viral infection of the vaginalmucosa. Antibiotic-treatedmice succumbed to mucosal herpes simplex virus type 2 infection more rapidly than water-fed mice, and also showed delayed viral clearance at the site of infection. However, innate immune responses, including type I IFN and proinflammatory cytokine production at infection sites, as well as induction of virus-specific CD4 and CD8 T-cell responses in draining lymph nodes, were not impaired in antibiotic-treated mice. By screening the factors controlling antiviral immunity, we found that IL-33, an alarmin released in response to tissue damage, was secreted from vaginal epithelium after the depletion of commensal microbiota. This cytokine suppresses local antiviral immunity by blocking the migration of effector T cells to the vaginal tissue, thereby inhibiting the production of IFN-gamma, a critical cytokine for antiviral defense, at local infection sites. These findings provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense.-
dc.languageEnglish-
dc.publisherNATL ACAD SCIENCES-
dc.titleDysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa-
dc.typeArticle-
dc.identifier.wosid000369571700013-
dc.identifier.scopusid2-s2.0-84957831444-
dc.type.rimsART-
dc.citation.volume196-
dc.citation.publicationnamePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.identifier.doi10.1073/pnas.1518589113-
dc.contributor.localauthorOh, Ji Eun-
dc.contributor.localauthorLee, Heung Kyu-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorcommensal microbiota-
dc.subject.keywordAuthordysbiosis-
dc.subject.keywordAuthorIL-33-
dc.subject.keywordAuthorherpes simplex virus type 2-
dc.subject.keywordAuthorgenital tract-
dc.subject.keywordPlusINNATE LYMPHOID-CELLS-
dc.subject.keywordPlusHERPES-SIMPLEX-VIRUS-
dc.subject.keywordPlusSERRATIA-MARCESCENS-
dc.subject.keywordPlusCOMMENSAL MICROBIOTA-
dc.subject.keywordPlusBACTERIAL VAGINOSIS-
dc.subject.keywordPlusADAPTIVE IMMUNITY-
dc.subject.keywordPlusHOST-DEFENSE-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusCYTOKINE-
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