Peripheral Serotonin: a New Player in Systemic Energy Homeostasis

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Whole body energy balance is achieved through the coordinated regulation of energy intake and energy expenditure in various tissues including liver, muscle and adipose tissues. A positive energy imbalance by excessive energy intake or insufficient energy expenditure results in obesity and related metabolic diseases. Although there have been many obesity treatment trials aimed at the reduction of energy intake, these strategies have achieved only limited success because of their associated adverse effects. An ancient neurotransmitter, serotonin is among those traditional pharmacological targets for anti-obesity treatment because it exhibits strong anorectic effect in the brain. However, recent studies suggest the new functions of peripheral serotonin in energy homeostasis ranging from the endocrine regulation by gut-derived serotonin to the autocrine/paracrine regulation by adipocyte-derived serotonin. Here, we discuss the role of serotonin in the regulation of energy homeostasis and introduce peripheral serotonin as a possible target for anti- obesity treatment.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2015-12
Language
English
Article Type
Review
Keywords

INCREASES CIRCULATING ADIPONECTIN; BRAIN-SEROTONIN; INSULIN-SECRETION; 5-HT RECEPTORS; ADIPOSE-TISSUE; D-FENFLURAMINE; BODY-WEIGHT; FIRING RATE; FOOD-INTAKE; MICE

Citation

MOLECULES AND CELLS, v.38, no.12, pp.1023 - 1028

ISSN
1016-8478
URI
http://hdl.handle.net/10203/206000
Appears in Collection
MSE-Journal Papers(저널논문)
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