DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고웅현 | ko |
dc.contributor.author | 홍정우 | ko |
dc.contributor.author | 신현준 | ko |
dc.contributor.author | 김철웅 | ko |
dc.contributor.author | 신현정 | ko |
dc.date.accessioned | 2016-04-20T06:30:59Z | - |
dc.date.available | 2016-04-20T06:30:59Z | - |
dc.date.created | 2015-09-24 | - |
dc.date.created | 2015-09-24 | - |
dc.date.created | 2015-09-24 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | 한국정밀공학회지, v.32, no.8, pp.755 - 760 | - |
dc.identifier.issn | 1225-9071 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205395 | - |
dc.description.abstract | For proper wound healing, dermal contraction and remodeling are critical; during the natural healing process, differentiated fibroblasts called “myofibroblasts” typically undertake these functions. For severe wounds, however, a critical mass of dermal matrix and fibroblasts are lost, making self-regeneration impossible. To overcome this impairment, synthetic wound patches with embedded functional cells can be used to promote healing. In this study, we developed a polydioxanone (PDO)-based cell-embedded sheet on which dermal fibroblasts were cultured and induced for differentiation into myofibroblasts, whereby the following combinatorial physicochemical stimuli were also applied: aligned topology, electric field (EF), and growth factor. The results show that both the aligned topology and EF synergistically enhanced the expression of alpha smooth-muscle actin (α-SMA), a key myofibroblast marker. Our proof-of-concept (POC) experiments demonstrated the potential applicability of a myofibroblast-embedded PDO sheet as a wound patch. | - |
dc.language | Korean | - |
dc.publisher | 한국정밀공학회 | - |
dc.title | 피부 재생능력 촉진을 위한 물리적 복합자극의 활용 연구 | - |
dc.title.alternative | Combinatorial Physical Stimulation and Synergistically-Enhanced Fibroblast Differentiation for Skin Regeneration | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 755 | - |
dc.citation.endingpage | 760 | - |
dc.citation.publicationname | 한국정밀공학회지 | - |
dc.identifier.doi | 10.7736/KSPE.2015.32.8.755 | - |
dc.identifier.kciid | ART002014830 | - |
dc.contributor.localauthor | 신현정 | - |
dc.contributor.nonIdAuthor | 김철웅 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Wound patch (상처패치) | - |
dc.subject.keywordAuthor | Fibroblast (근섬유아세포) | - |
dc.subject.keywordAuthor | Electrospinning (전기방사) | - |
dc.subject.keywordAuthor | Polydioxanone (PDO) (폴리디옥사논) | - |
dc.subject.keywordAuthor | Electrical stimulation (전기자극) | - |
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