DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bapat, Sagar P. | ko |
dc.contributor.author | Suh, Jae Myoung | ko |
dc.contributor.author | Fang, Sungsoon | ko |
dc.contributor.author | Liu, Sihao | ko |
dc.contributor.author | Zhang, Yang | ko |
dc.contributor.author | Cheng, Albert | ko |
dc.contributor.author | Zhou, Carmen | ko |
dc.contributor.author | Liang, Yuqiong | ko |
dc.contributor.author | LeBlanc, Mathias | ko |
dc.contributor.author | Liddle, Christopher | ko |
dc.contributor.author | Atkins, Annette R. | ko |
dc.contributor.author | Yu, Ruth T. | ko |
dc.contributor.author | Downes, Michael | ko |
dc.contributor.author | Evans, Ronald M. | ko |
dc.contributor.author | Zheng, Ye | ko |
dc.date.accessioned | 2016-04-20T06:09:58Z | - |
dc.date.available | 2016-04-20T06:09:58Z | - |
dc.date.created | 2015-11-26 | - |
dc.date.created | 2015-11-26 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | NATURE, v.528, no.7580, pp.137 - 137 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205130 | - |
dc.description.abstract | Age-associated insulin resistance (IR) and obesity-associated IR are two physiologically distinct forms of adult-onset diabetes. While macrophage-driven inflammation is a core driver of obesity-associated IR1-6, the underlying mechanisms of the obesity-independent yet highly prevalent age-associated IR7 are largely unexplored. Here we show, using comparative adipo-immune profiling in mice, that fat-resident regulatory T cells, termed fT(reg) cells, accumulate in adipose tissue as a function of age, but not obesity. Supporting the existence of two distinct mechanisms underlying IR, mice deficient in fT(reg) cells are protected against age-associated IR, yet remain susceptible to obesity-associated IR and metabolic disease. By contrast, selective depletion of fT(reg) cells via anti-ST2 antibody treatment increases adipose tissue insulin sensitivity. These findings establish that distinct immune cell populations within adipose tissue underlie ageing- and obesity-associated IR, and implicate fT(reg) cells as adipo-immune drivers and potential therapeutic targets in the treatment of age-associated IR. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | VISCERAL ADIPOSE-TISSUE | - |
dc.subject | RNA-SEQ | - |
dc.subject | ORCHESTRATE DEVELOPMENT | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | BEIGE FAT | - |
dc.subject | MACROPHAGES | - |
dc.subject | OBESITY | - |
dc.subject | INFLAMMATION | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | ACCUMULATION | - |
dc.title | Depletion of fat-resident T-reg cells prevents age-associated insulin resistance | - |
dc.type | Article | - |
dc.identifier.wosid | 000365606000064 | - |
dc.identifier.scopusid | 2-s2.0-84949257630 | - |
dc.type.rims | ART | - |
dc.citation.volume | 528 | - |
dc.citation.issue | 7580 | - |
dc.citation.beginningpage | 137 | - |
dc.citation.endingpage | 137 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/nature16151 | - |
dc.contributor.localauthor | Suh, Jae Myoung | - |
dc.contributor.nonIdAuthor | Bapat, Sagar P. | - |
dc.contributor.nonIdAuthor | Fang, Sungsoon | - |
dc.contributor.nonIdAuthor | Liu, Sihao | - |
dc.contributor.nonIdAuthor | Zhang, Yang | - |
dc.contributor.nonIdAuthor | Cheng, Albert | - |
dc.contributor.nonIdAuthor | Zhou, Carmen | - |
dc.contributor.nonIdAuthor | Liang, Yuqiong | - |
dc.contributor.nonIdAuthor | LeBlanc, Mathias | - |
dc.contributor.nonIdAuthor | Liddle, Christopher | - |
dc.contributor.nonIdAuthor | Atkins, Annette R. | - |
dc.contributor.nonIdAuthor | Yu, Ruth T. | - |
dc.contributor.nonIdAuthor | Downes, Michael | - |
dc.contributor.nonIdAuthor | Evans, Ronald M. | - |
dc.contributor.nonIdAuthor | Zheng, Ye | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | VISCERAL ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | RNA-SEQ | - |
dc.subject.keywordPlus | ORCHESTRATE DEVELOPMENT | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | BEIGE FAT | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ACCUMULATION | - |
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