Label-Free and Real-Time Detection of Avian Influenza Using Nanowire Field Effect Transistors

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Real-time and label-free detection of antibodies from avian influenza (anti-Al) in an aqueous solution is demonstrated with the use of a nanowire field effect transistor. A real-time measurement system is constructed without leakage paths through the solution medium. The current through the nanowire changes significantly after an injection of an anti-Al solution onto the device, which was previously functionalized by the antigen of Al as a probe of anti-Al. In contrast, no significant response arises when an anti-Al solution is injected onto a non-functionalized device. Therefore, the real-time detection of specific antibody-antigen interaction of the Al is successfully implemented for a chip-based biosensor.
Publisher
AMER SCIENTIFIC PUBLISHERS
Issue Date
2015-09
Language
English
Article Type
Article
Citation

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v.11, no.9, pp.1640 - 1643

ISSN
1550-7033
DOI
10.1166/jbn.2015.1501
URI
http://hdl.handle.net/10203/203185
Appears in Collection
CBE-Journal Papers(저널논문)EE-Journal Papers(저널논문)
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