DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Suk-Ho | ko |
dc.contributor.author | Sohn, Jong Woo | ko |
dc.contributor.author | Ahn, Seung-Cheol | ko |
dc.contributor.author | Park, Won-Sun | ko |
dc.contributor.author | Ho, Won-Kyung | ko |
dc.date.accessioned | 2015-11-20T13:01:43Z | - |
dc.date.available | 2015-11-20T13:01:43Z | - |
dc.date.created | 2014-03-28 | - |
dc.date.created | 2014-03-28 | - |
dc.date.issued | 2004-04 | - |
dc.identifier.citation | NEUROPHARMACOLOGY, v.46, no.5, pp.638 - 646 | - |
dc.identifier.issn | 0028-3908 | - |
dc.identifier.uri | http://hdl.handle.net/10203/201835 | - |
dc.description.abstract | Defects in GABAergic interneurons are thought to be involved in the pathophysiology of bipolar disorder, and Li+ has been used as a primary therapeutic agent in the treatment. We used the patch clamp technique to investigate whether Li+ affects on spontaneous GABAergic synaptic inputs to granule cells (GCs) in hippocampal dentate gyrus. Extracellularly applied Li+ (25 mM) markedly increased the frequency and amplitude of spontaneous inhibitory postsynaptic currents (slPSCs), ail effect completely blocked by picrotoxin or bicuculline. Li+ increased slPSCs frequency in die presence of tetrodotoxin (TTX), but to a lesser extent than its absence. Li+ caused no change in the cumulative amplitude distribution of miniature IPSCs, indicating that a presynaptic mechanism is involved. When TTX was added in the presence of Li+, large-amplitude slPSCs (>30 pA) were abolished specifically with no effect on small-amplitude slPSCs (<20 pA). Intracellular Li+ (6 mM) applied via the patch pipette depolarized the resting membrane potential in fast-spiking interneurons, resulting in ail increase in spontaneous action potential (AP) firing. This change, however, was not observed in GCs. These results suggest that Li+-induced spontaneous AP firing in GABAergic interneurons contributes to the increase in GABAergic synaptic inputs to GCs. (C) 2004 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | MOUSE CEREBRAL-CORTEX | - |
dc.subject | BIPOLAR DISORDER | - |
dc.subject | LITHIUM ACTION | - |
dc.subject | INTERNEURONS | - |
dc.subject | GLUTAMATE | - |
dc.subject | NEURONS | - |
dc.subject | SCHIZOPHRENIA | - |
dc.subject | ACCUMULATION | - |
dc.subject | SYNAPSE | - |
dc.subject | RELEASE | - |
dc.title | Li+ enhances GABAergic inputs to granule cells in the rat hippocampal dentate gyrus | - |
dc.type | Article | - |
dc.identifier.wosid | 000220613700004 | - |
dc.identifier.scopusid | 2-s2.0-1442299857 | - |
dc.type.rims | ART | - |
dc.citation.volume | 46 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 638 | - |
dc.citation.endingpage | 646 | - |
dc.citation.publicationname | NEUROPHARMACOLOGY | - |
dc.identifier.doi | 10.1016/j.neuropharm.2003.11.008 | - |
dc.contributor.localauthor | Sohn, Jong Woo | - |
dc.contributor.nonIdAuthor | Lee, Suk-Ho | - |
dc.contributor.nonIdAuthor | Ahn, Seung-Cheol | - |
dc.contributor.nonIdAuthor | Park, Won-Sun | - |
dc.contributor.nonIdAuthor | Ho, Won-Kyung | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | lithium | - |
dc.subject.keywordAuthor | granule cell | - |
dc.subject.keywordAuthor | IPSC | - |
dc.subject.keywordAuthor | bipolar affective disorder | - |
dc.subject.keywordAuthor | interneuron | - |
dc.subject.keywordPlus | MOUSE CEREBRAL-CORTEX | - |
dc.subject.keywordPlus | BIPOLAR DISORDER | - |
dc.subject.keywordPlus | LITHIUM ACTION | - |
dc.subject.keywordPlus | INTERNEURONS | - |
dc.subject.keywordPlus | GLUTAMATE | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | SYNAPSE | - |
dc.subject.keywordPlus | RELEASE | - |
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