Li+ enhances GABAergic inputs to granule cells in the rat hippocampal dentate gyrus

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dc.contributor.authorLee, Suk-Hoko
dc.contributor.authorSohn, Jong Wooko
dc.contributor.authorAhn, Seung-Cheolko
dc.contributor.authorPark, Won-Sunko
dc.contributor.authorHo, Won-Kyungko
dc.date.accessioned2015-11-20T13:01:43Z-
dc.date.available2015-11-20T13:01:43Z-
dc.date.created2014-03-28-
dc.date.created2014-03-28-
dc.date.issued2004-04-
dc.identifier.citationNEUROPHARMACOLOGY, v.46, no.5, pp.638 - 646-
dc.identifier.issn0028-3908-
dc.identifier.urihttp://hdl.handle.net/10203/201835-
dc.description.abstractDefects in GABAergic interneurons are thought to be involved in the pathophysiology of bipolar disorder, and Li+ has been used as a primary therapeutic agent in the treatment. We used the patch clamp technique to investigate whether Li+ affects on spontaneous GABAergic synaptic inputs to granule cells (GCs) in hippocampal dentate gyrus. Extracellularly applied Li+ (25 mM) markedly increased the frequency and amplitude of spontaneous inhibitory postsynaptic currents (slPSCs), ail effect completely blocked by picrotoxin or bicuculline. Li+ increased slPSCs frequency in die presence of tetrodotoxin (TTX), but to a lesser extent than its absence. Li+ caused no change in the cumulative amplitude distribution of miniature IPSCs, indicating that a presynaptic mechanism is involved. When TTX was added in the presence of Li+, large-amplitude slPSCs (>30 pA) were abolished specifically with no effect on small-amplitude slPSCs (<20 pA). Intracellular Li+ (6 mM) applied via the patch pipette depolarized the resting membrane potential in fast-spiking interneurons, resulting in ail increase in spontaneous action potential (AP) firing. This change, however, was not observed in GCs. These results suggest that Li+-induced spontaneous AP firing in GABAergic interneurons contributes to the increase in GABAergic synaptic inputs to GCs. (C) 2004 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectMOUSE CEREBRAL-CORTEX-
dc.subjectBIPOLAR DISORDER-
dc.subjectLITHIUM ACTION-
dc.subjectINTERNEURONS-
dc.subjectGLUTAMATE-
dc.subjectNEURONS-
dc.subjectSCHIZOPHRENIA-
dc.subjectACCUMULATION-
dc.subjectSYNAPSE-
dc.subjectRELEASE-
dc.titleLi+ enhances GABAergic inputs to granule cells in the rat hippocampal dentate gyrus-
dc.typeArticle-
dc.identifier.wosid000220613700004-
dc.identifier.scopusid2-s2.0-1442299857-
dc.type.rimsART-
dc.citation.volume46-
dc.citation.issue5-
dc.citation.beginningpage638-
dc.citation.endingpage646-
dc.citation.publicationnameNEUROPHARMACOLOGY-
dc.identifier.doi10.1016/j.neuropharm.2003.11.008-
dc.contributor.localauthorSohn, Jong Woo-
dc.contributor.nonIdAuthorLee, Suk-Ho-
dc.contributor.nonIdAuthorAhn, Seung-Cheol-
dc.contributor.nonIdAuthorPark, Won-Sun-
dc.contributor.nonIdAuthorHo, Won-Kyung-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorlithium-
dc.subject.keywordAuthorgranule cell-
dc.subject.keywordAuthorIPSC-
dc.subject.keywordAuthorbipolar affective disorder-
dc.subject.keywordAuthorinterneuron-
dc.subject.keywordPlusMOUSE CEREBRAL-CORTEX-
dc.subject.keywordPlusBIPOLAR DISORDER-
dc.subject.keywordPlusLITHIUM ACTION-
dc.subject.keywordPlusINTERNEURONS-
dc.subject.keywordPlusGLUTAMATE-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusSCHIZOPHRENIA-
dc.subject.keywordPlusACCUMULATION-
dc.subject.keywordPlusSYNAPSE-
dc.subject.keywordPlusRELEASE-
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