DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Changsik | ko |
dc.contributor.author | Han, Jae-A | ko |
dc.contributor.author | Koh, Hyein | ko |
dc.contributor.author | Choi, Bongseo | ko |
dc.contributor.author | Cho, Yongbin | ko |
dc.contributor.author | Jeong, Hyeongmin | ko |
dc.contributor.author | Ra, Jea-Sun | ko |
dc.contributor.author | Sung, Pil Soo | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Ryu, Seongho | ko |
dc.contributor.author | Do, Yoonkyung | ko |
dc.date.accessioned | 2015-11-20T08:56:32Z | - |
dc.date.available | 2015-11-20T08:56:32Z | - |
dc.date.created | 2015-07-30 | - |
dc.date.created | 2015-07-30 | - |
dc.date.created | 2015-07-30 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | CELL REPORTS, v.11, no.12, pp.1929 - 1940 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/200892 | - |
dc.description.abstract | Recent studies on T follicular helper (Tfh) cells have significantly advanced our understanding of T cell-dependent B cell responses. However, little is known about the early stage of Tfh cell commitment by dendritic cells (DCs), particularly by the conventional CD8 alpha(+) and CD8 alpha(-) DC subsets. We show that CD8 alpha(-) DCs localized at the interfollicular zone play a pivotal role in the induction of antigen-specific Tfh cells by upregulating the expression of Icosl and Ox40l through the non-canonical NF-kappa B signaling pathway. Tfh cells induced by CD8 alpha(-) DCs function as true B cell helpers, resulting in significantly increased humoral immune responses against various human pathogenic antigens, including Yersinia pestis LcrV, HIV Gag, and hepatitis B surface antigen. Our findings uncover a mechanistic role of CD8 alpha(-) DCs in the initiation of Tfh cell differentiation and thereby provide a rationale for investigating CD8 alpha(-) DCs in enhancing antigen-specific humoral immune responses for improving vaccines and therapeutics. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | CXC CHEMOKINE RECEPTOR-5 | - |
dc.subject | HEPATITIS-B-VACCINE | - |
dc.subject | IN-VIVO | - |
dc.subject | ANTIBODY-PRODUCTION | - |
dc.subject | HIV-INFECTION | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | EXPRESSION | - |
dc.subject | MOUSE | - |
dc.subject | ICOS | - |
dc.subject | FOLLICLES | - |
dc.title | CD8 alpha(-) Dendritic Cells Induce Antigen-Specific T Follicular Helper Cells Generating Efficient Humoral Immune Responses | - |
dc.type | Article | - |
dc.identifier.wosid | 000357393500009 | - |
dc.identifier.scopusid | 2-s2.0-84933678575 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1929 | - |
dc.citation.endingpage | 1940 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2015.05.042 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Shin, Changsik | - |
dc.contributor.nonIdAuthor | Han, Jae-A | - |
dc.contributor.nonIdAuthor | Koh, Hyein | - |
dc.contributor.nonIdAuthor | Choi, Bongseo | - |
dc.contributor.nonIdAuthor | Cho, Yongbin | - |
dc.contributor.nonIdAuthor | Jeong, Hyeongmin | - |
dc.contributor.nonIdAuthor | Ra, Jea-Sun | - |
dc.contributor.nonIdAuthor | Ryu, Seongho | - |
dc.contributor.nonIdAuthor | Do, Yoonkyung | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CXC CHEMOKINE RECEPTOR-5 | - |
dc.subject.keywordPlus | HEPATITIS-B-VACCINE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ANTIBODY-PRODUCTION | - |
dc.subject.keywordPlus | HIV-INFECTION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | ICOS | - |
dc.subject.keywordPlus | FOLLICLES | - |
dc.subject.keywordPlus | CXC CHEMOKINE RECEPTOR-5 | - |
dc.subject.keywordPlus | HEPATITIS-B-VACCINE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ANTIBODY-PRODUCTION | - |
dc.subject.keywordPlus | HIV-INFECTION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | ICOS | - |
dc.subject.keywordPlus | FOLLICLES | - |
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