Chemical Genetics Approach Reveals Importance of cAMP and MAP Kinase Signaling to Lipid and Carotenoid Biosynthesis in Microalgae

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In this study, we attempted to understand signaling pathways behind lipid biosynthesis by employing a chemical genetics approach based on small molecule inhibitors. Specific signaling inhibitors of MAP kinase or modulators of cAMP signaling were selected to evaluate the functional roles of each of the key signaling pathways in three different microalgal species: Chlamydomonas reinhardtii, Chlorella vulgaris, and Haematococcus pluvialis. Our results clearly indicate that cAMP signaling pathways are indeed positively associated with microalgal lipid biosynthesis. In contrast, MAP kinase pathways in three microalgal species are all negatively implicated in both lipid and carotenoid biosynthesis.
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Issue Date
2015-05
Language
English
Article Type
Article
Keywords

CHLAMYDOMONAS-REINHARDTII; FUNGAL DEVELOPMENT; VIRULENCE; PATHWAYS; ASTAXANTHIN; PIGMENTS; ALGAE

Citation

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.25, no.5, pp.637 - 647

ISSN
1017-7825
DOI
10.4014/jmb.1408.08035
URI
http://hdl.handle.net/10203/199475
Appears in Collection
CBE-Journal Papers(저널논문)
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