DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Dae-Hwan | ko |
dc.contributor.author | Kim, Byung Hun | ko |
dc.contributor.author | Lim, Yong Taik | ko |
dc.contributor.author | Kim, Jaiwook | ko |
dc.contributor.author | Lee, SangYup | ko |
dc.contributor.author | Jung, HeeTae | ko |
dc.date.accessioned | 2010-11-12T07:32:51Z | - |
dc.date.available | 2010-11-12T07:32:51Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | CARBON, v.48, no.4, pp.1070 - 1078 | - |
dc.identifier.issn | 0008-6223 | - |
dc.identifier.uri | http://hdl.handle.net/10203/19840 | - |
dc.description.abstract | Single-walled carbon nanotubes (SWCNTs) dotted with Au nanocrystals (Au-SWCNTs) were fabricated by using a two-phase reduction of hydrogen tetrachloroaurate in the presence of thiol groups anchored to SWCNTs for their potential applications in DNA (deoxyribonucleic acid) delivery. To allow a surface reaction on SWCNTs during the metal nucleation and growth processes, Au nanocrystals were grown using a two-phase system. Raman, XPS and transmission electron microscopy results show that the Au nanocrystals were grafted primarily to the sidewalls of the SWCNTs. DNA probes were immobilized on Au-SWCNTs by the conjugation of DNA functionalized at the 3' end with a thiol group with Au dots of SWCNTs, followed by hybridizion of complementary oligonucleotides, as verified by fluorescence-based measurements. To investigate whether the target DNA hybridized to DNA probes immobilized on Au-SWCNTs, 618-base-pair fragments of amplified DNA were prepared by polymerase chain reaction using plasmid pET-22b as a template. Atomic force micrograph (AFM) images show that the nanorod-bound DNA is recognizable with excellent specificity, indicating the potential use of such material as a versatile gene delivery carrier in gene-based disease therapy. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This work was supported by the National R&D Project for Nano Science and Technology and the Brain Korea 21 Program. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Fabrication of single-walled carbon nanotubes dotted with Au nanocrystals: Potential DNA delivery nanocarriers | - |
dc.type | Article | - |
dc.identifier.wosid | 000274829500017 | - |
dc.identifier.scopusid | 2-s2.0-74149092690 | - |
dc.type.rims | ART | - |
dc.citation.volume | 48 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 1070 | - |
dc.citation.endingpage | 1078 | - |
dc.citation.publicationname | CARBON | - |
dc.identifier.doi | 10.1016/j.carbon.2009.11.028 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, SangYup | - |
dc.contributor.localauthor | Jung, HeeTae | - |
dc.contributor.nonIdAuthor | Lim, Yong Taik | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SELF-ASSEMBLED MONOLAYERS | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | SPECTRA | - |
dc.subject.keywordPlus | RAMAN | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ELECTRODES | - |
dc.subject.keywordPlus | CHEMISTRY | - |
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