Production of lactic acid from red algal galactan and its recovery by membrane separation = 홍조류 갈락탄으로부터 젖산 생산 및 막분리를 이용한 회수

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A process has been developed for lactic acid production from red algal galactan. This process consists of four steps: 1) saccharification of red algal galactan; 2) detoxification of the acid hydrolysate; 3) production of lactic acid from the detoxified hydrolysate by fermentation; and 4) lactic acid recovery from the fermentation broth by membrane separation. First, for the saccharification of agarose, the main component of red algal galactan, hydrochloric acid (HCl) was used. Agarose was readily hydrolyzed to galactose, 5-hydroxymethylfurfural (5-HMF), and levulinic acid by HCl. To overcome disadvantages of liquid acid catalysis such as excessive acid consumption with no reuse and waste generation during the subsequent neutralization step, HCl was replaced by a solid acid catalyst, Amberlyst 36. In order to identify optimal reaction conditions, the effects of reaction time, temperature and catalyst concentration on galactose yield and production rate were investigated. In the subsequent step, a nanofiltration (NF) process with TFC-SR3 membrane was employed for the removal of 5-HMF and levulinic acid from the acid hydrolysate. 5-HMF and levulinic acid are inhibitory to fermentation, but at the same time they themselves are useful compounds with many applications. The effects of various operating parameters such as pH, temperature and feed composition were investigated. Galactose rejection remained constant at a very high level over 0.99 with no respect to the pressure, while the rejections of 5-HMF and levulinic acid ranged from 0.03 to 0.13 and from 0.17 to 0.46 respectively, indicating that the NF process was very effective for the removal of 5-HMF and levulinic acid while retaining galactose. For the complete removal of 5-HMF and levulinic acid, NF in a diafiltration mode was carried out. In the subsequent step of electrodialysis (ED), 5-HMF and levulinic acid could be effectively separated from each other. The feasibility of lactic acid production from gal...
Advisors
Chang, Yong-Keunresearcher장용근
Description
한국과학기술원 : 생명화학공학과,
Publisher
한국과학기술원
Issue Date
2013
Identifier
565550/325007  / 020097018
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2013.8, [ xiii, 152 p. ]

Keywords

Lactic acid; 모델링; 전기투석; 나노여과; 홍조류 갈락탄; 젖산; Red algal galactan; Nanofiltration; Electrodialysis; Modeling

URI
http://hdl.handle.net/10203/196361
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=565550&flag=dissertation
Appears in Collection
CBE-Theses_Ph.D.(박사논문)
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