Vaccine delivery application of microneedles = 마이크로니들을 이용한 백신 전달

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A vaccine is a biological preparation against specific disease. Ever since vaccines were first found by E. Jenner, the continuing development of vaccines has dramatically improved the quality of human life and successfully helped eradicate several infectious diseases, such as smallpox and measles. However, most of diseases such as HIV, remain in uncovered by vaccination. Today, the conventional vaccines are varied by the type of antigen, formulation, and delivery tool. In this paper, we focus on the delivery tools to improve the efficacy of vaccines.Some of the traditional vaccine delivery methods include the intramuscular, subcutaneous and intradermal injection using a hypodermic syringe. However, these methods induce pain, fear, and stress caused by syringes and necessitate trained health care professionals. In addition, the use of invasive needles could cause needle-stick injuries and blood-borne infections resulting from syringe injections. Moreover, the issue of needle reuse in developed countries and lack of trained health care professionals in pandemic seasons show the limitation of conventional delivery tools. To overcome such disadvantages, novel vaccination tools have been progressively developed. For example, research studies dealing with mucosal vaccination targets the mucosal tissues via the ocular, nasal, sublingual, pulmonary and gastrointestinal routes for improving the immunogenicity and protection of vaccines. In other cases, transcutaneous immunization using liquid jet injection, epidermal powder injection and patches were introduced. In this paper, the microneedle patch, one of the methods in transcutaneous vaccination, were used for delivering vaccines or drugs. The microneedle patch, an array of micrometer-sized needles, does not induce pain resulting from injection of invasive needles, so it markedly improves the patient compliance. Furthermore, it is possible to deliver vaccines into the skin, which is rich in immune cells, and stimulat...
Kim, Yeu-Chunresearcher김유천
한국과학기술원 : 생명화학공학과,
Issue Date
568936/325007  / 020123375

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2014.2, [ 44 p. ]


Vaccine; 비강후사; 표면처리; 인플루엔자; 마이크로니들; 백신; microneedle; influenza; surface treatment; intranasal vaccination

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