Nucleoredoxin promotes adipogenic differentiation through regulation of Wnt/beta-catenin signaling

Cited 7 time in webofscience Cited 0 time in scopus
  • Hit : 546
  • Download : 0
Nucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. We found that NRX expression levels were higher in white adipose tissue of obese ob/ob mice and increased in the early adipogenic stage of 3T3-L1 preadipocyte differentiation. Knockdown of NRX decreased differentiation of 3T3-L1 cells, whereas overexpression increased differentiation. Adipose tissue-specific NRX transgenic mice showed increases in adipocyte size as well as number compared with WT mice. We further confirmed that the Wingless/int-1 class (Wnt)/-catenin pathway was also involved in NRX-promoted adipogenesis, consistent with a previous report showing NRX regulation of this pathway. Genes involved in lipid metabolism were downregulated, whereas inflammatory genes, including those encoding macrophage markers, were significantly upregulated, likely contributing to the obesity in Adipo-NRX mice. Our results therefore suggest that NRX acts as a novel proadipogenic factor and controls obesity in vivo.
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Issue Date
2015-02
Language
English
Article Type
Article
Keywords

WHITE ADIPOSE-TISSUE; BETA-CATENIN; INSULIN-RESISTANCE; OBESITY; THIOREDOXIN; PROTEIN; DISEASE; GENE; EXPRESSION; BIOLOGY

Citation

JOURNAL OF LIPID RESEARCH, v.56, no.2, pp.294 - 303

ISSN
0022-2275
DOI
10.1194/jlr.M054056
URI
http://hdl.handle.net/10203/195551
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 7 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0