DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwak, Shinae | ko |
dc.contributor.author | Huh, Namjung | ko |
dc.contributor.author | Seo, Ji-Seon | ko |
dc.contributor.author | Lee, Jung-Eun | ko |
dc.contributor.author | Han, Pyung-Lim | ko |
dc.contributor.author | Jung, MinWhan | ko |
dc.date.accessioned | 2015-04-07T05:00:53Z | - |
dc.date.available | 2015-04-07T05:00:53Z | - |
dc.date.created | 2014-12-16 | - |
dc.date.created | 2014-12-16 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v.8 | - |
dc.identifier.issn | 1662-5153 | - |
dc.identifier.uri | http://hdl.handle.net/10203/195249 | - |
dc.description.abstract | In order to investigate roles of dopamine receptor subtypes in reward-based learning, we examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Performance of D2R-KO mice was progressively impaired in the former as the frequency of reversal increased and profoundly impaired in the latter even with prolonged training, whereas DI R-KO mice showed relatively minor performance deficits. Choice behavior in the dynamic two-armed bandit task was well explained by a hybrid model including win-stay-lose-switch and reinforcement learning terms. A model-based analysis revealed increased win-stay, but impaired value updating and decreased value-dependent action selection in D2R-KO mice, which were detrimental to maximizing rewards in the dynamic two-armed bandit task. These results suggest an important role of dopamine D2 receptors in learning from past choice outcomes for rapid adjustment of choice behavior in a dynamic and uncertain environment. | - |
dc.language | English | - |
dc.publisher | FRONTIERS RESEARCH FOUNDATION | - |
dc.subject | DISCRIMINATION REVERSAL TASK | - |
dc.subject | NUCLEUS-ACCUMBENS | - |
dc.subject | DECISION-MAKING | - |
dc.subject | PREFRONTAL CORTEX | - |
dc.subject | MIDBRAIN DOPAMINE | - |
dc.subject | AVERSIVE BEHAVIOR | - |
dc.subject | DISTINCT ROLES | - |
dc.subject | BASAL GANGLIA | - |
dc.subject | D2-LIKE RECEPTORS | - |
dc.subject | STRIATAL NEURONS | - |
dc.title | Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment | - |
dc.type | Article | - |
dc.identifier.wosid | 000347895600001 | - |
dc.identifier.scopusid | 2-s2.0-84908391187 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.publicationname | FRONTIERS IN BEHAVIORAL NEUROSCIENCE | - |
dc.identifier.doi | 10.3389/fnbeh.2014.00368 | - |
dc.contributor.localauthor | Jung, MinWhan | - |
dc.contributor.nonIdAuthor | Kwak, Shinae | - |
dc.contributor.nonIdAuthor | Huh, Namjung | - |
dc.contributor.nonIdAuthor | Seo, Ji-Seon | - |
dc.contributor.nonIdAuthor | Lee, Jung-Eun | - |
dc.contributor.nonIdAuthor | Han, Pyung-Lim | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | D1 receptor | - |
dc.subject.keywordAuthor | D2 receptor | - |
dc.subject.keywordAuthor | reversal | - |
dc.subject.keywordAuthor | dynamic foraging task | - |
dc.subject.keywordAuthor | mouse | - |
dc.subject.keywordAuthor | reinforcement learning | - |
dc.subject.keywordPlus | DISCRIMINATION REVERSAL TASK | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | DECISION-MAKING | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | MIDBRAIN DOPAMINE | - |
dc.subject.keywordPlus | AVERSIVE BEHAVIOR | - |
dc.subject.keywordPlus | DISTINCT ROLES | - |
dc.subject.keywordPlus | BASAL GANGLIA | - |
dc.subject.keywordPlus | D2-LIKE RECEPTORS | - |
dc.subject.keywordPlus | STRIATAL NEURONS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.