Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment

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In order to investigate roles of dopamine receptor subtypes in reward-based learning, we examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Performance of D2R-KO mice was progressively impaired in the former as the frequency of reversal increased and profoundly impaired in the latter even with prolonged training, whereas DI R-KO mice showed relatively minor performance deficits. Choice behavior in the dynamic two-armed bandit task was well explained by a hybrid model including win-stay-lose-switch and reinforcement learning terms. A model-based analysis revealed increased win-stay, but impaired value updating and decreased value-dependent action selection in D2R-KO mice, which were detrimental to maximizing rewards in the dynamic two-armed bandit task. These results suggest an important role of dopamine D2 receptors in learning from past choice outcomes for rapid adjustment of choice behavior in a dynamic and uncertain environment.
Publisher
FRONTIERS RESEARCH FOUNDATION
Issue Date
2014-10
Language
English
Article Type
Article
Keywords

DISCRIMINATION REVERSAL TASK; NUCLEUS-ACCUMBENS; DECISION-MAKING; PREFRONTAL CORTEX; MIDBRAIN DOPAMINE; AVERSIVE BEHAVIOR; DISTINCT ROLES; BASAL GANGLIA; D2-LIKE RECEPTORS; STRIATAL NEURONS

Citation

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v.8

ISSN
1662-5153
DOI
10.3389/fnbeh.2014.00368
URI
http://hdl.handle.net/10203/195249
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
Kwak S._Role of dopamine D2_Front. Behav. Neurosci._2014.pdf(2.14 MB)Download
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