DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sangjin | ko |
dc.contributor.author | Sonn, Jun Young | ko |
dc.contributor.author | Oh, Yang Kyun | ko |
dc.contributor.author | Lim, Chunghun | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2014-12-16T01:15:01Z | - |
dc.date.available | 2014-12-16T01:15:01Z | - |
dc.date.created | 2014-10-27 | - |
dc.date.created | 2014-10-27 | - |
dc.date.created | 2014-10-27 | - |
dc.date.created | 2014-10-27 | - |
dc.date.created | 2014-10-27 | - |
dc.date.created | 2014-10-27 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | MOLECULES AND CELLS, v.37, no.4, pp.295 - 301 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | http://hdl.handle.net/10203/192803 | - |
dc.description.abstract | SIFamide receptor (SIFR) is a Drosophila G protein-coupled receptor for the neuropeptide SIFamide (SIFa). Although the sequence and spatial expression of SIFa are evolutionarily conserved among insect species, the physiological function of SIFa/SIFR signaling remains elusive. Here, we provide genetic evidence that SIFa and SIFR promote sleep in Drosophila. Either genetic ablation of SIFa-expressing neurons in the pars intercerebralis (PI) or pan-neuronal depletion of SIFa expression shortened baseline sleep and reduced sleep-bout length, suggesting that it caused sleep fragmentation. Consistently, RNA interference-mediated knockdown of SIFR expression caused short sleep phenotypes as observed in SIFa-ablated or depleted flies. Using a panel of neuron-specific Gal4 drivers, we further mapped SIFR effects to subsets of PI neurons. Taken together, these results reveal a novel physiological role of the neuropeptide SIFa/SIFR pathway to regulate sleep through sleep-promoting neural circuits in the PI of adult fly brains. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | SIFamide and SIFamide Receptor Define a Novel Neuropeptide Signaling to Promote Sleep in Drosophila | - |
dc.type | Article | - |
dc.identifier.wosid | 000342560000003 | - |
dc.identifier.scopusid | 2-s2.0-84901404010 | - |
dc.type.rims | ART | - |
dc.citation.volume | 37 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 295 | - |
dc.citation.endingpage | 301 | - |
dc.citation.publicationname | MOLECULES AND CELLS | - |
dc.identifier.doi | 10.14348/molcells.2014.2371 | - |
dc.contributor.localauthor | Lim, Chunghun | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Drosophila melanogaster | - |
dc.subject.keywordAuthor | Pars Intercerebralis | - |
dc.subject.keywordAuthor | sleep | - |
dc.subject.keywordAuthor | SIFamide | - |
dc.subject.keywordAuthor | SIFamide receptor | - |
dc.subject.keywordPlus | MUSHROOM BODIES | - |
dc.subject.keywordPlus | OCTOPAMINE | - |
dc.subject.keywordPlus | SCREEN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CONSOLIDATION | - |
dc.subject.keywordPlus | MELANOGASTER | - |
dc.subject.keywordPlus | WAKEFULNESS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
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