OncoSearch: cancer gene search engine with literature evidence

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In order to identify genes that are involved in oncogenesis and to understand how such genes affect cancers, abnormal gene expressions in cancers are actively studied. For an efficient access to the results of such studies that are reported in biomedical literature, the relevant information is accumulated via text-mining tools and made available through the Web. However, current Web tools are not yet tailored enough to allow queries that specify how a cancer changes along with the change in gene expression level, which is an important piece of information to understand an involved gene's role in cancer progression or regression. OncoSearch is a Web-based engine that searches Medline abstracts for sentences that mention gene expression changes in cancers, with queries that specify (i) whether a gene expression level is up-regulated or down-regulated, (ii) whether a certain type of cancer progresses or regresses along with such gene expression change and (iii) the expected role of the gene in the cancer.
Publisher
OXFORD UNIV PRESS
Issue Date
2014-07
Language
English
Article Type
Article
Citation

NUCLEIC ACIDS RESEARCH, v.42, no.W1, pp.W416 - W421

ISSN
0305-1048
DOI
10.1093/nar/gku368
URI
http://hdl.handle.net/10203/192614
Appears in Collection
CS-Journal Papers(저널논문)
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