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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Kaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation

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dc.contributor.authorLiang, Qimingko
dc.contributor.authorChang, Brianko
dc.contributor.authorBrulois, Kevin F.ko
dc.contributor.authorCastro, Kamilahko
dc.contributor.authorMin, Chan-Kiko
dc.contributor.authorRodgers, Mary A.ko
dc.contributor.authorShi, Mudeko
dc.contributor.authorGe, Jianningko
dc.contributor.authorFeng, Pinghuiko
dc.contributor.authorOh, Byung-Hako
dc.contributor.authorJung, Jae U.ko
dc.date.accessioned2014-12-09T01:42:05Z-
dc.date.available2014-12-09T01:42:05Z-
dc.date.created2013-11-19-
dc.date.created2013-11-19-
dc.date.issued2013-11-
dc.identifier.citationJOURNAL OF VIROLOGY, v.87, no.22, pp.12499 - 12503-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10203/192464-
dc.description.abstractAutophagy is an important innate safeguard mechanism for protecting an organism against invasion by pathogens. We have previously discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) evades this host defense through tight suppression of autophagy by targeting multiple steps of autophagy signal transduction. Here, we report that KSHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagy-mediated host immunity for its life cycle.-
dc.languageEnglish-
dc.publisherAMER SOC MICROBIOLOGY-
dc.subjectREGULATORY FACTOR 7-
dc.subjectPROTEIN-
dc.subjectPHOSPHORYLATION-
dc.subjectCOMPLEX-
dc.subjectTARGETS-
dc.subjectATG14L-
dc.subjectUVRAG-
dc.subjectORF45-
dc.subjectLC3-
dc.titleKaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation-
dc.typeArticle-
dc.identifier.wosid000325865400050-
dc.identifier.scopusid2-s2.0-84886303412-
dc.type.rimsART-
dc.citation.volume87-
dc.citation.issue22-
dc.citation.beginningpage12499-
dc.citation.endingpage12503-
dc.citation.publicationnameJOURNAL OF VIROLOGY-
dc.identifier.doi10.1128/JVI.01898-13-
dc.contributor.localauthorOh, Byung-Ha-
dc.contributor.nonIdAuthorLiang, Qiming-
dc.contributor.nonIdAuthorChang, Brian-
dc.contributor.nonIdAuthorBrulois, Kevin F.-
dc.contributor.nonIdAuthorCastro, Kamilah-
dc.contributor.nonIdAuthorMin, Chan-Ki-
dc.contributor.nonIdAuthorRodgers, Mary A.-
dc.contributor.nonIdAuthorShi, Mude-
dc.contributor.nonIdAuthorGe, Jianning-
dc.contributor.nonIdAuthorFeng, Pinghui-
dc.contributor.nonIdAuthorJung, Jae U.-
dc.type.journalArticleArticle-
dc.subject.keywordPlusREGULATORY FACTOR 7-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusTARGETS-
dc.subject.keywordPlusATG14L-
dc.subject.keywordPlusUVRAG-
dc.subject.keywordPlusORF45-
dc.subject.keywordPlusLC3-
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