Electrochemical Immunosensing Chip Using Selective Surface Modification, Capillary-Driven Microfluidic Control, and Signal Amplification by Redox Cycling

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A sensitive electrochemical immunosensing chip is presented by employing (i) selective modification of protein-resistant surfaces; (ii) fabrication of a stable Ag/AgCl reference electrode; (iii) capillary-driven microfluidic control; (iv) signal amplification by redox cycling along with enzymatic reaction. Purely capillary-driven microfluidic control is combined with electrochemical sandwich-type immunosensing procedure. Selective modification of the surfaces is achieved by chemical reactivity-controlled patterning and electrochemical deposition. Fluidic control of the immunosensing chip is achieved by spontaneous capillary-driven flows and passive washing. The detection limit for mouse IgG in the immunosensing chip is 10 pg/mL.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2010-10
Language
English
Article Type
Article
Keywords

TIN OXIDE ELECTRODE; GLUCOSE SENSOR; AVIDIN-BINDING; ELECTROPHORESIS; DEVICES; FLOW; POLY(DIMETHYLSILOXANE); NANOPARTICLES; BIOSENSORS; STABILITY

Citation

ELECTROANALYSIS, v.22, no.19, pp.2235 - 2244

ISSN
1040-0397
URI
http://hdl.handle.net/10203/192399
Appears in Collection
BS-Journal Papers(저널논문)
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