High frame-rate intravascular optical frequency-domain imaging in vivo

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Intravascular optical frequency-domain imaging (OFDI), a second-generation optical coherence tomography (OCT) technology, enables imaging of the three-dimensional (3D) microstructure of the vessel wall following a short and nonocclusive clear liquid flush. Although 3D vascular visualization provides a greater appreciation of the vessel wall and intraluminal structures, a longitudinal imaging pitch that is several times bigger than the optical imaging resolution of the system has limited true high-resolution 3D imaging, mainly due to the slow scanning speed of previous imaging catheters. Here, we demonstrate high frame-rate intravascular OFDI in vivo, acquiring images at a rate of 350 frames per second. A custom-built, high-speed, and high-precision fiber-optic rotary junction provided uniform and high-speed beam scanning through a custom-made imaging catheter with an outer diameter of 0.87 mm. A 47-mm-long rabbit aorta was imaged in 3.7 seconds after a short contrast agent flush. The longitudinal imaging pitch was 34 mu m, comparable to the transverse imaging resolution of the system. Three-dimensional volumerendering showed greatly enhanced visualization of tissue microstructure and stent struts relative to what is provided by conventional intravascular imaging speeds.
Publisher
OPTICAL SOC AMER
Issue Date
2014-01
Language
English
Article Type
Article
Citation

BIOMEDICAL OPTICS EXPRESS, v.5, no.1, pp.223 - 232

ISSN
2156-7085
DOI
10.1364/BOE.5.5.000223
URI
http://hdl.handle.net/10203/188700
Appears in Collection
ME-Journal Papers(저널논문)
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