DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Ki-Seok | ko |
dc.contributor.author | Ha, Unsoo | ko |
dc.contributor.author | Lee, Jae Hyuk | ko |
dc.contributor.author | Bong, Kyeongryeol | ko |
dc.contributor.author | Yoo, Hoi-Jun | ko |
dc.date.accessioned | 2014-08-29T01:08:41Z | - |
dc.date.available | 2014-08-29T01:08:41Z | - |
dc.date.created | 2014-01-27 | - |
dc.date.created | 2014-01-27 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.citation | IEEE JOURNAL OF SOLID-STATE CIRCUITS, v.49, no.1, pp.167 - 178 | - |
dc.identifier.issn | 0018-9200 | - |
dc.identifier.uri | http://hdl.handle.net/10203/188697 | - |
dc.description.abstract | A bio-feedback iontophoresis controller IC is implemented into a fabric patch for transdermal drug delivery. An iontophoresis stimulator front-end (ISFE) can provide programmable stimulation current in the range of 16-512-mu A amplitude, DC-500-Hz frequency, and 3% -100% duty cycle for controllable drug delivery. For safe and robust electrical stimulation, a failure detection circuit monitors the stimulation current to prevent overcurrent and stimulation voltage saturation. For bio-feedback operation, a dual-mode impedance sensor (DMIS) measures load and tissue impedances in the range of 5-50 k Omega and 5 Omega-1 k Omega, respectively. In the DMIS, the gain of a programmable gain amplifier and the injected current level of a chopper-modulated current source are automatically controlled to minimize power consumption. The proposed IC occupies 2.35 mm 2.35 mm including pads in a 0.11-mu m 1P6M CMOS technology and dissipates a peak power of 2.2 mW. The proposed IC is directly integrated on a 9 cm 4 cm fabric circuit board together with a 6.2-mAh coin battery for convenient iontophoresis treatment. The proposed system provides a maximum dosage range of 87 mA, which is larger range than the 80-mA dosage range of a commercial iontophoresis patch. Using a reconfigurable tetra-polar electrode configuration, load and tissue impedances are measured during the iontophoresis treatment to provide bio-feedback. The proposed iontophoresis system is successfully verified by both in-vitro and in-vivo tests. | - |
dc.language | English | - |
dc.publisher | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | - |
dc.subject | IN-VIVO | - |
dc.subject | SKIN | - |
dc.title | An 87-mA . Iontophoresis Controller IC With Dual-Mode Impedance Sensor for Patch-Type Transdermal Drug Delivery System | - |
dc.type | Article | - |
dc.identifier.wosid | 000329052700016 | - |
dc.identifier.scopusid | 2-s2.0-84891623816 | - |
dc.type.rims | ART | - |
dc.citation.volume | 49 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 167 | - |
dc.citation.endingpage | 178 | - |
dc.citation.publicationname | IEEE JOURNAL OF SOLID-STATE CIRCUITS | - |
dc.identifier.doi | 10.1109/JSSC.2013.2282090 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Yoo, Hoi-Jun | - |
dc.contributor.nonIdAuthor | Bong, Kyeongryeol | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Bio-feedback electrical stimulation | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | failure detection | - |
dc.subject.keywordAuthor | impedance sensor | - |
dc.subject.keywordAuthor | iontophoresis | - |
dc.subject.keywordAuthor | tissue impedance | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SKIN | - |
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