When a compact microchannel heat exchanger is operated at cryogenic environments, it has potential problems of axial conduction and flow maldistribution. To analyze these detrimental effects, the heat exchanger model that includes both axial conduction and flow maldistribution effect is developed in consideration of the microchannel heat exchanger geometry. A dimensionless axial conduction parameter (lambda) is used to describe the axial conduction effect, and the coefficient of variation (Coy) is introduced to quantify the flow maldistribution condition. The effectiveness of heat exchanger is calculated according to the various values of the axial conduction parameter and the CoV. The analysis results show that the heat exchanger effectiveness is insensitive when lambda is less than 0.005, and effectiveness is degraded with the large value of CoV. Three microchannel heat exchangers are fabricated with printed circuit heat exchanger (PCHE) technology for validation purpose of the heat exchanger model. The first heat exchanger is a conventional heat exchanger, the second heat exchanger has the modified cross section to eliminate axial conduction effect, and the third heat exchanger has the modified cross section and the cross link in parallel channel to mitigate flow maldistribution effect. These heat exchangers are tested in cryogenic single-phase, and two-phase environments. The third heat exchanger shows the ideal thermal characteristic, while the other two heat exchangers experience some performance degradation due to axial conduction or flow maldistribution. The impact of axial conduction and flow maldistribution effects are verified by the simulation results and compared with the experimental results. (C) 2014 Elsevier Ltd. All rights reserved.