Spontaneous Local Gamma Oscillation Selectively Enhances Neural Network Responsiveness

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Synchronized oscillation is very commonly observed in many neuronal systems and might play an important role in the response properties of the system. We have studied how the spontaneous oscillatory activity affects the responsiveness of a neuronal network, using a neural network model of the visual cortex built from Hodgkin-Huxley type excitatory (E-) and inhibitory (I-) neurons. When the isotropic local E-I and I-E synaptic connections were sufficiently strong, the network commonly generated gamma frequency oscillatory firing patterns in response to random feed-forward (FF) input spikes. This spontaneous oscillatory network activity injects a periodic local current that could amplify a weak synaptic input and enhance the network's responsiveness. When E-E connections were added, we found that the strength of oscillation can be modulated by varying the FF input strength without any changes in single neuron properties or interneuron connectivity. The response modulation is proportional to the oscillation strength, which leads to self-regulation such that the cortical network selectively amplifies various FF inputs according to its strength, without requiring any adaptation mechanism. We show that this selective cortical amplification is controlled by E-E cell interactions. We also found that this response amplification is spatially localized, which suggests that the responsiveness modulation may also be spatially selective. This suggests a generalized mechanism by which neural oscillatory activity can enhance the selectivity of a neural network to FF inputs.
Publisher
PUBLIC LIBRARY SCIENCE
Issue Date
2009-04
Language
English
Article Type
Article
Keywords

MONKEY STRIATE CORTEX; CAT VISUAL-CORTEX; NEURONAL SYNCHRONIZATION; SYNAPTIC-INTERACTIONS; INTERNEURON NETWORKS; PYRAMIDAL NEURONS; GAIN MODULATION; MECHANISM; POTENTIALS; ATTENTION

Citation

PLOS COMPUTATIONAL BIOLOGY, v.5, no.4

ISSN
1553-734X
DOI
10.1371/journal.pcbi.1000342
URI
http://hdl.handle.net/10203/182926
Appears in Collection
BiS-Journal Papers(저널논문)
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